Title Function and Dysfunction of the Cochlea
Subtitle From Mechanisms to Potential Therapies
Author Guy P. Richardson, Christine Petit
ISBN 9781621822790
List price USD 135.00
Price outside India Available on Request
Original price
Binding Hardbound
No of pages 348
Book size 184 X 260 mm
Publishing year 2019
Original publisher Cold Spring Harbor Laboratory Press
Published in India by .
Exclusive distributors Viva Books Private Limited
Sales territory India, Sri Lanka, Bangladesh, Pakistan, Nepal, .
Status New Arrival
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The cochlea, the mammalian auditory organ, is a spiral-shaped structure in the inner ear that is responsible for hearing. It converts sound vibrations into electrical signals and sends them to the brain with a remarkable temporal precision. Defects in the cellular or molecular components of the cochlea can lead to deafness and other hearing impairments.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the complex molecular mechanisms that are responsible for cochlear function and were, for the most part, revealed by the discovery of genes responsible for hearing impairment. It describes major advances in our understanding of the pathogenic processes underlying various forms of hearing loss and the emergence of treatments for deafness. The contributors focus on the highly specialized cells which mediate auditory transduction—the hair cells—and their unique architectural, mechanical, and molecular characteristics. They also consider the properties of other cochlear components, including the tectorial membrane, the synaptic connections with auditory neurons, and the resident macrophages, as well as the development and evolution of the cochlea as a whole. Topics such as hair cell regeneration, otoacoustic emissions, and ototoxicity are also discussed.

In addition, the authors examine the epidemiology of hearing loss and emerging, innovative, therapeutic strategies (e.g., gene therapy, optical cochlear implants). This volume is therefore a valuable reference for cell biologists and neuroscientists interested in the biology of hearing, as well as physician–scientists seeking new approaches to alleviate hearing impairments.



A Functional Perspective on the Evolution of the Cochlea (Christine Köppl and Geoffrey A. Manley)

Cochlear Frequency Tuning and Otoacoustic Emissions (Christopher A. Shera and Karolina K. Charaziak)

Active Biomechanics of Sensory Hair Bundles (Dolores Bozovic)

Development and Patterning of the Cochlea: From Convergent Extension to Planar Polarity (Mireille Montcouquiol and Matthew W. Kelley)

Hair-Bundle Links: Genetics as the Gateway to Function (Guy P. Richardson and Christine Petit)

Function and Dysfunction of TMC Channels in Inner Ear Hair Cells (David P. Corey, Nurunisa Akyuz, and Jeffrey R. Holt)

Molecular Structure of the Hair Cell Mechanoelectrical Transduction Complex (Christopher L. Cunningham and Ulrich Müller)

Molecular Composition of Vestibular Hair Bundles (Jocelyn F. Krey and Peter G. Barr-Gillespie)

The Tectorial Membrane: Mechanical Properties and Functions (Jonathan B. Sellon, Roozbeh Ghaffari, and Dennis M. Freeman)

Hair Cell Afferent Synapses: Function and Dysfunction (Stuart L. Johnson, Saaid Safieddine, Mirna Mustapha, and Walter Marcotti)

Outer Hair Cells and Electromotility (Jonathan Ashmore)

Efferent Inhibition of the Cochlea (Paul Albert Fuchs and Amanda M. Lauer)

Inner Ear Connexin Channels: Roles in Development and Maintenance of Cochlear Function (Fabio Mammano)

The Epidemiology of Deafness (Abraham M. Sheffield and Richard J.H. Smith)

Hidden Hearing Loss: A Disorder with Multiple Etiologies and Mechanisms (David Kohrman, Guoqiang Wan, Luis Cassinotti, and Gabriel Corfas)

Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies (Corné J. Kros and Peter S. Steyger)

Age-Related Hearing Loss (Michael R. Bowl and Sally J. Dawson)

Interactions between Macrophages and the Sensory Cells of the Inner Ear (Mark E. Warchol)

Stem Cells and the Bird Cochlea—Where Is Everybody? (Amanda S. Janesick and Stefan Heller)

Cochlear Gene Therapies (Lawrence Lustig and Omar Akil)

Toward the Optical Cochlear Implant (Tobias Dombrowski, Vladan Rankovic, and Tobias Moser)


Target Audience:

People interested in Cell Biology; Human Biology and Disease. Also a valuable reference for neuroscientists interested in the biology of hearing, as well as physician–scientists seeking new approaches to alleviate hearing impairments.

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