Title Physiology and Pathophysiology of Digestion
Author D. Neil Granger, James Morris, Peter R. Kvietys
ISBN 9781615046966
List price USD 99.95
Price outside India Available on Request
Original price
Binding Paperback
No of pages 338
Book size 191 X 235 mm
Publishing year 2018
Original publisher Morgan & Claypool Publishers (Eurospan Group)
Published in India by .
Exclusive distributors Viva Books Private Limited
Sales territory India, Sri Lanka, Bangladesh, Pakistan, Nepal, .
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This collaboration of two physiologists and a gastroenterologist provides medical and graduate students, medical and surgical residents, and subspecialty fellows a comprehensive summary of digestive system physiology and addresses the pathophysiological processes that underlie some GI diseases. The textual approach proceeds by organ instead of the traditional organization followed by other GI textbooks. This approach lets the reader track the food bolus as it courses through the GI tract, learning on the way each organ’s physiologic functions as the bolus directly or indirectly contacts it. The book is divided into three parts: (1) Chapters 1–3 include coverage of basic concepts that pertain to all (or most) organs of the digestive system, salivation, chewing, swallowing, and esophageal function, (2) Chapters 4–6 are focused on the major secretory organs (stomach, pancreas, liver) that assist in the assimilation of a meal, and (3) Chapters 7 and 8 address the motor, transport, and digestive functions of the small and large intestines. Each chapter includes its own pathophysiology and clinical correlation section that underscores the importance of the organ’s normal function.



Chapter 1: Basic Concepts • Introduction • Control of Gastrointestinal Function • The Enteroendocrine System • Gastrointestinal Hormones and Related Peptides • Intrinsic and Extrinsic Nerves • Intrinsic Innervation • Extrinsic Innervation • Parasympathetics • Sympathetics • Afferent Nerve Fibers • Sensory Transduction • Gastrointestinal Functions • Motility • Basal Electrical Rhythm and Interestitial Cells of Cajal • Excitation-Contraction Coupling • Functional Motor Patterns • Digestion • Absorption • Routes of Absorption • Mechanisms of Absorption • Passive Absorption • Active Absorption • Water Absorption • Secretion • Water and Electrolyte Secretion • Mucin Secretion • Circulation of the Digestive System • Pathophysiology and Clinical Correlations • References

Chapter 2: Eating, Salivation, Chewing, and Swallowing • Introduction • Physiology of Hunger and Thirst • Hunger • Thirst • Salivary Glands • Water and Electrolyte Secretion • Composition and Function of Saliva • Regulation of Salivary Secretion • Neural Control • Parasympathetics • Sympathetics • Hormonal Regulation • Stimuli for Salivary Secretion • Salivary Blood Flow • Chewing (Mastication) • Mechanisms • Functions • Swallowing (Deglutition) • Pin in the Mouth and Oropharynx • Pathophysiology and Clinical Correlations • Salivary Glands • Deglutition • References

Chapter 3: The Esophagus • Introduction • Anatomic Considerations • Innervation • Extrinsic • Intrinsic • Esophagal Function • The Interdigestive Period • The Ingestive Period • Esophageal Motor Events Associated with Retrograde Transport • Mechanisms Preventing Gastroesophageal Reflux • Esophageal Pain • Pathophysiology and Clinical Correlations • Gastroesophageal Reflux Disease (GERD) • Motility Disorders • References

Chapter 4: The Stomach • Introduction • General Anatomical Features of the Stomach • Gastric Secretion • Mucosal Glands • Acid Secretion • Pepsinogen and Lipase Secretion • Functions of Gastric Acid and Pepsin • Mucus Secretion • Functions of Mucus • Integrated Regulation of Gastric Secretion • Interprandial (Basal) Acid Secretion • Postprandial Secretion • Gastric Motility • Microscopic Anatomy of the Muscularis • Electrical and Contractile Activity of Smooth Muscle • Gastric Accommodation • Transpyloric Movement of Chyme • Gastric Emptying • Integrated Regulation of Gastric Motility • Interpranclial (Basal) Motility • Postprandial Motility • Overview of the Gastric Response to a Meal • Gastric Blood Flow • Gastric Mucosal Growth • Gastric Mucosal Defense • Vomiting (Emesis) • Pain Sensations from the Stomach • Pathophysiology and Clinical Correlations • Peptic Ulcer Diseases • Helicobacter Pylori (H. pylori)Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) • Gastroparesis (Impaired Gastric Emptying) • References

Chapter 5: The Pancreas • Introduction • Anatomy • Regulation of Pancreatic Mass • Composition and Formation of Pancreatic Juice • Electrolytes • Proteins • Regulation of Pancreatic Secretion • Endocrine and Paracrine Regulation • Neural/Neurocrine Regulation • Potentiation of Secretory Responses • Feedback Regulation of Pancreatic Secretion • Overview of Pancreatic Secretory Response to Meals • Basal Secretion • Cephalic Phase of Secretion • Gastric Phase of Secretion • Intestinal Phase of Secretion • Functions of Pancreatic Juice • Bicarbonate • Enzymes • The Pancreatic Circulation • Functional Implications of a Portal Circulation • Role of the Microcirculation in Pancreatic Secretion • Pancreatic Pain • Pathophysiology and Clinical Correlations • References

Chapter 6: The Liver and Biliary Tree • Introduction • Functional Anatomy of the Liver and Biliary Tree • Macroscopic Anatomy • Microscopic Anatomy • Hepatocyte Growth and Regeneration • Composition of Bile • Hepatic Bile • Gallbladder Bile • Mechanisms of Hepatic Bile Formation • Canalicular Bile Formation • Bile Acid-Dependent Secretion • Bile Acid-Independent Secretion • Ductal Component of Bile Flow • The Gallbladder: Anatomy and Function • Water and Electrolyte Transport • Motor Functions • The Enterohepatic Circulation • Fate of Bile Salts in the Intestine • Transport of Absorbed Bile Salts to Liver and Resecretion into Bile • Regulation of the Biliary System • Bile Salt Concentration in Portal Blood • Gastrointestinal Hormones • Secretion • Cholecystokinin • Other Hormones • Nervous Influences • Parasympathetics • Sympathetics • The Hepatic Circulation • Liver and Biliary Pain • Pathophysiology and Clinical Correlations • Gallstones • Conditions Associated with Hepatocellular Injury • References

Chapter 7: The Small Intestine • Introduction • Anatomy • Serosa • Muscularis Externa • Submucosa • Mucosa • Muscularis Mucosae • Lamina Propria • Epithelium • Mucosal Growth and Adaptation • Water and Electrolyte Absorption • Water Absorption • Electrolyte Absorption • Sodium • Potassium • Chloride • Bicarbonate • Calcium • Magnesium • Iron • Secretion of Water and Electrolytes • Carbohydrate Digestion and Absorption • Dietary Carbohydrates • Digestion • Transport of Monosaccharides • Carbohydrate Intolerance • Dietary Fiber • Protein Digestion and Absorption • Dietary Requirements • Digestion • Luminal Digestion • Cellular Digestion of Peptides • Peptide and Amino Acid Transport Mechanisms • Peptides • Amino Acids • Absorption of Native Proteins • Nucleoprotein Digestion and Absorption • Water-Soluble Vitamins • Folates • Cobalamin • Lipid Digestion and Absorption • Dietary Lipids • Triglyceride Digestion • Phospholipid Digestion • Cholestrol Digestion • Solubilization of Lipid Digestion Products • Cellular Uptake of Lipolytic Products • Intracellular Metabolism of Lipid Digestion Products • Monoglycrides and Fatty Acids • Cholesterol • Phospholipids • Chylomicron Formation and Transport • Absorption of Fat-Soluble Vitamins • Motility • Electrical and Contractile Activity of Smooth Muscle • Neural Regulation of Motility • Functional Patterns of Intestinal Muscle Contractions • Interdigestive Pattern • Digestive Pattern • Segmentation • Peristaltic Wave • Initiation of Postprandial Motility Pattern • Villus Contractions • Transit Time of Chyme • The Ileocecal Junction • Sphincter Function • Transjunctional Flow • Defensive Motor Patterns • Power Propulsion • Giant Migrating Contractions (GMCs) • Retrograde Peristaltic Contractions (RPCs) • Inhibition of Propulsion • Intestino-Intestinal Reflex • Ileal Brake • Intestinal Circulation • Small Intestinal Pain • Pathophysiology and Clinical Correlations • References

Chapter 8: The Large Intestine • Introduction • Anatomy • Serosa • Muscularis Externa • Mucosa • Epithelial Cells • Mucosal Growth and Adaptation • Water and Electrolyte Transport • Water Transport • Electrolyte Transport • Sodium • Potassium • Chloride and Bicarbonate • Digestion and Absorption of Food Residues • Enteric Microbiota • Fermentation of Carbohydrates and Proteins • Bile Acid Metabolism • Vitamin Production and Absorption • Ammonia Metabolism in the Colon • Colonic Gas • Motility • Intrinsic Influences • Neural and Humoral Influences • Patterns of Contractions • Effects of Feeding on Colonic Motility • Defecation • Anatomic Considerations • Innervation of the Rectum and Anal Sphincters • Reflex Activity of the Anal Sphincters • Continence • Act of Defecation • Colonic Circulation • Colonic Pain • Pathophysiology and Clinical Correlations • References

Author Biographies

About the Authors:

D. Neil Granger, Ph.D., is Boyd Professor Emeritus in the Department of Molecular and Cellular Physiology at the LSU Health Sciences Center in Shreveport, Louisiana. His research interests have been focused on the role of the microcirculation in acute and chronic inflammation and how risk factors for cardiovascular disease influence microvascular function. Dr. Granger has a longstanding record of teaching physiology to medical and graduate students. He has served on the editorial boards of the GI & Liver, Heart & Circulation, and Cell sections of the American Journal of Physiology, as well as Circulation Research, Microcirculation, Shock, Pathophysiology, Free Radical Biology & Medicine, Lymphatic Research and Biology, and Nitric Oxide Biology & Chemistry. He was an Associate Editor of the American Journal of Physiology: GI & Liver Physiology and the Editor-in-Chief of Microcirculation.

James D. Morris, MD., FACG, FACP, AGAF, is an Associate Professor of Medicine in the Department of Medicine at the Louisiana State University (LSU) Health Sciences Center in Shreveport, Louisiana. He serves as a clinical educator actively seeing patients and engaged in educational activities for all levels of medical students, residents, and gastroenterology fellows. He currently serves as the Program Director for the Gastroenterology fellowship after previously serving as the Associate Program Director for three years. He also is involved in the medical curriculum for medical students as the Co-Course Director of the undergraduate medical student course in gastrointestinal and liver diseases. He has worked in the area of colon cancer screening education research and inflammatory bowel disease trials.

Peter R. Kvietys, Ph.D., is a Professor of Physiology at Alfaisal University and a Scientist in the Department of Cell Biology at King Faisal Specialist Hospital and Research Center in Riyadh, Saudi Arabia. He received his Ph.D. from Michigan State University in East Lansing, Michigan. Dr. Kvietys has been a consultant for various government agencies both in the United States (e.g., NIH) and Canada (e.g., CIHR). He has served as an Associate Editor of the American Journal of Physiology: Gastrointestinal & Liver Physiology. Dr. Kvietys has published numerous research articles and several books dealing with various aspects of gastrointestinal physiology and pathophysiology.

Target Audience:

Intended for medical and graduate students, medical and surgical residents, and subspecialty fellows.


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