Title Cancer Genomics for the Clinician
Subtitle
Author Ramaswamy Govindan, Siddhartha Devarakonda
ISBN 9780826168672
List price USD 55.00
Price outside India Available on Request
Original price
Binding Paperback
No of pages 184
Book size 127 x 203 mm
Publishing year 2019
Original publisher Demos Medical Publishing
Published in India by .
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Sales territory Bangladesh, India, Pakistan, Sri Lanka
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Description:

Cancer Genomics for the Clinician is a practical guide to cancer genomics and its application to cancer diagnosis and care. The book begins with a brief overview of the various types of genetic alterations that are encountered in cancer, followed by accessible and applicable information on next generation sequencing technology and bioinformatics; tumor heterogeneity; whole genome, exome, and transcriptome sequencing; epigenomics; and data analysis and interpretation. Each chapter provides essential explanations of concepts, terminology, and methods. Also included are tips for interpreting and analyzing molecular data, as well as a discussion of molecular predictors for targeted therapies covering hematologic malignancies and solid tumors. The final chapter explains the use of FDA-approved genomic-based targeted therapies for breast cancer, lung cancer, sarcomas, gastrointestinal cancers, urologic cancers, head and neck cancer, thyroid cancer, and many more.

Assembled in an accessible format specifically designed for the non-expert, this book provides the clinical oncologist, early career practitioner, and trainee with an essential understanding of the molecular and genetic basis of cancer and the clinical aspects that have led to advancements in diagnosis and treatment. With this resource, physicians and trainees will increase their breadth of knowledge and be better equipped to educate patients and families who want to know more about their genetic predispositions to cancer and the targeted therapies that could be considered and prescribed.

Key Features:

  • Describes how cancer genomics and next generation sequencing informs cancer screening, risk factors, therapeutic options, and clinical management across cancer types
  • Explains what mutations are, what tests are needed, and how to interpret the results
  • Provides information on FDA-approved targeted therapies that are being used in the clinic
  • Covers different sequencing platforms and technologies and how they perform in research settings
  • Includes access to the fully searchable eBook

Contents:

Contributors

Preface

Acknowledgments

Share Cancer Genomics for the Clinician

Chapter 1: Genetic Alterations in Cancer (Deepali Jain, Brett H. Herzog, and Leonard B. Maggi, Jr.)

Chapter 2: Tumor Mutational Profiling by Next-Generation Sequencing (Samantha N. McNulty, Latisha Love-Gregory, and Jonathan W. Heusel)

Chapter 3: Bioinformatics: What a Clinician Should Know (Irena Lanc and Arpad Danos)

Chapter 4: Tumor Heterogeneity (Alex H. Wagner, Kilannin Krysiak, Katie M. Campbell, and Erica K. Barnell)

Chapter 5: Epigenetic Alterations in Cancer (Erica C. Pehrsson, Hyo Sik Jang, and Ting Wang)

Chapter 6: Cell-Free DNA in Cancer Diagnosis and Follow Up (Bruna Pellini Ferreira and Daniel Morgensztern)

Chapter 7: Optimizing Targeted Therapies Using Next-Generation Sequencing (Brett H. Herzog and Saiama N. Waqar)

Index

About the Editors:

Ramaswamy Govindan, MD, Anheuser Busch Endowed Chair in Medical Oncology, Professor in Department of Medicine, Oncology Division and Director of Section of Medical Oncology, Washington University Medical School in St. Louis, St. Louis, Missouri.

Siddhartha Devarakonda, MD, is Assistant Professor Department of Medicine, Oncology Division and Medical Oncology, Washington University Medical School in St. Louis, St. Louis, Missouri.

Target Audience:

This book is useful for Clinical Oncologists, early career practitioners, and trainees in diagnosis and treatment of cancer.

 

 
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