Title Next-Generation Sequencing in Medicine
Author W. Richard McCombie, Elaine R. Mardis, James A. Knowles, John D. McPherson
ISBN 9781621821137
List price USD 135.00
Price outside India Available on Request
Original price
Binding Hardbound
No of pages 250
Book size 184 X 260 mm
Publishing year 2019
Original publisher Cold Spring Harbor Laboratory Press
Published in India by .
Exclusive distributors Viva Books Private Limited
Sales territory India, Sri Lanka, Bangladesh, Pakistan, Nepal, .
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Next-generation sequencing technologies have the capacity to generate large numbers of DNA sequence reads at relatively high speed and low cost. These technologies have revolutionized biomedical research and are increasingly employed in clinical settings, where they can be used to detect inherited disorders, predict disease risk, and personalize therapies.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines next-generation sequencing technologies and their use, particularly in translational research. The contributors discuss the various sequencing platforms, their capabilities, and their applications in both research and clinical practice. The roles of next-generation sequencing in diagnosing autism and intellectual disabilities, monitoring cancers during disease progression, and determining the most appropriate drug treatments for patients are also covered.

In addition, the authors consider the practical challenges (e.g., data storage) and ethical implications of using next-generation sequencing technologies. This volume is therefore an essential read for all scientists and physicians interested in these technologies and how they are impacting biomedicine.



Next-Generation Sequencing Technologies (W. Richard McCombie, John D. McPherson, and Elaine R. Mardis)

Next-Generation Sequencing Strategies (Shawn E. Levy and Braden E. Boone)

Single-Cell Applications of Next-Generation Sequencing (Naishitha Anaparthy, Yu-Jui Ho, Luciano Martelotto, Molly Hammell, and James Hicks)

Sequencing in High Definition Drives a Changing Worldview of the Epigenome (Emily Hodges)

Clinical Versus Research Sequencing (Yuriy Shevchenko and Sherri Bale)

High-Throughput Sequencing and Assessing Disease Risk (Shannon M. Rego and Michael P. Snyder)

The Use of Next-Generation Sequencing for Research and Diagnostics for Intellectual Disability (Ricardo Harripaul, Abdul Noor, Muhammad Ayub, and John B. Vincent)

Next-Generation Sequencing in Autism Spectrum Disorder (Stephan J. Sanders)

The Role of Next-Generation Sequencing in Pharmacogenetics and Pharmacogenomics (Ute I. Schwarz, Markus Gulilat, and Richard B. Kim)

Whole-Genome Sequencing in Cancer (Eric Y. Zhao, Martin Jones, and Steven J.M. Jones)

Characterizing the Cancer Genome in Blood (Sarah-Jane Dawson)

The Impact of Next-Generation Sequencing on Cancer Genomics: From Discovery to Clinic (Ealine R. Mardis)

Next-Generation Sequencing and the Return of Results (Bartha Maria Knoppers, Minh Thu Nguyen, Karine Senecal, Anne Marie Tasse, and Ma’n H. Zawati)

Future Promise and Concerns of Ubiquitous Next-Generation Sequencing (W. Richard McCombie and John D. McPherson)


Target Audience:

People interested in Human Biology and Disease; and Molecular Biology.

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