Title Parkinson’s Disease Management through ICT: The REMPARK Approach
Subtitle (River Publishers Series in Biomedical Engineering)
Author Joan Cabestany, Àngels Bayés
ISBN 9788793519466
List price USD 132.00
Price outside India Available on Request
Original price
Binding Hardbound
No of pages 250
Book size 153 x 235 mm
Publishing year 2017
Original publisher River Publishers (Eurospan Group)
Published in India by .
Exclusive distributors Viva Books Private Limited
Sales territory India, Sri Lanka, Bangladesh, Pakistan, Nepal, .
Status New Arrival
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Parkinson’s Disease (PD) is a neurodegenerative disorder that manifests with motor and non-motor symptoms. PD treatment is symptomatic and tries to alleviate the associated symptoms through an adjustment of the medication. As the disease is evolving and this evolution is patient specific, it could be very difficult to properly manage the disease.

The current available technology (electronics, communication, computing, etc.), correctly combined with wearables, can be of great use for obtaining and processing useful information for both clinicians and patients allowing them to become actively involved in their condition.

Parkinson’s Disease Management through ICT: The REMPARK Approach presents the work done, main results and conclusions of the REMPARK project (2011 - 2015) funded by the European Union under contract FP7-ICT-2011-7-287677. REMPARK system was proposed and developed as a real Personal Health Device for the Remote and Autonomous Management of Parkinson’s Disease, composed of different levels of interaction with the patient, clinician and carers, and integrating a set of interconnected sub-systems: sensor, auditory cueing, Smartphone and server. The sensor subsystem, using embedded algorithmics, is able to detect the motor symptoms associated with PD in real time. This information, sent through the Smartphone to the REMPARK server, is used for an efficient management of the disease.

Implementation of REMPARK will increase the independence and Quality of Life of patients; and improve their disease management, treatment and rehabilitation.



List of Contributors

List of Figures

List of Tables

List of Abbreviations

Chapter 1: Parkinson’s Disease Management: Trends and Challenges
Angels Bayés and Timothy J Counihan

Introduction • Impact and Strategies of PD at Different Stages • Patients in Early Stages • Moderately Affected Patients • Severely Affected Patients • QoL in PD • State of Art of Current Trends in PD Management • Needs and Challenges for Optimal PD Manage • Conclusion • References

Chapter 2: Objective Measurement of Symptoms in PD
Timothy J Counihan and Angels Bayés

Advancing Parkinson’s Disease: Motor and Non-Motor • Fluctuations • Motor Fluctuations • Non-Motor Fluctuations • Challenges in Documenting “Real-World” Fluctuating PD Symptoms • Emerging Technologies to Monitor Symptom Fluctuations • Challenges in the Use of Inertial Sensor Technology in Monitoring PD Symptoms • Conclusion • References

Chapter 3: The REMPARK System
Joan Cabestany, J Manuel Moreno and Rui Castro

Introduction • REMPARK System Overview • The Immediate Level • The Mid-Term Level • Definition of the REMPARK System Main Characteristics • Subsystems Specification • Sensor Module • Auditory Cueing Subsystem • Gait guidance ACS functional description • Need of an adaptive ACS • Drug Delivery Pump Considerations • The smartphone Technical Requirements • The REMPARK Platform Architecture and Functionality • Important functional parts • Rule Engine • Disease Management System • Platform technical constraints • Conclusion • References

Chapter 4: Assessment of Motor Symptoms
Albert Sama, Carlos Pérez, Daniel Rodriguez-Martin, • Alejandro Rodriguez-Molinero, Sheila Alcaine, Berta Mestre, Anna Prats and M Cruz Crespo

Introduction • Decision on the Most Relevant Symptoms to Be Detected and Assessed • Subjects • Questionnaire • Results • Analysis of the correlation between responses on clinical questions • Investigation of the clinical relevance of the motor symptoms in the three PD phases (ie, mild, moderate and advanced) • Analysis of REMPARK utility for PD patients • Discussion and Conclusive Remarks • Methodology and Database to Monitor Motor Symptoms • An Artificial Intelligence Approach and the Need of Relevant Data • Protocol for the Database Construction • Gathered Database Description • Algorithmic Approach and Results • Dyskinesia Detection Algorithm • Bradykinesia Detection Algorithm • Tremor Detection Algorithm • Freezing of Gait (FOG) Detection Algorithm • Gait Parameters Estimation • Fall Detection Algorithm • ON/OFF Motor State Estimation • Conclusions • References

Chapter 5: Sensor Sub-System
Carlos Pérez and Daniel Rodriguez-Martin

Introduction • Sensor’s Data Processing Flow • Hardware Requirements • Memory Requirements • Sampling Frequency and Full-Scale Values • Time Restrictions on the On-Line Implementation • Sensor Device Components • Microcontroller • Accelerometer Details • Bluetooth Module • Power Management • External Memory Unit • Sensor Casing and Operation • Conclusion • References

Chapter 6: User Interaction
Ana Correira de Barros, João Cevada and Ricardo Graça

Introduction • State of the Art/Competitive Analysis • Interaction Guidelines for Users with Parkinson’s Disease • User Research and User-Centred Design Processes • Final Usability Tests • Research Questions • Sample • Protocol, Script and Metrics • Results • Appointment test • Medication test • Conclusions after the User-Centred Process • Characteristics of REMPARK Smartphone Applications • Some Concluding Remarks • References

Chapter 7: Actuator Sub-System: The Auditory Cueing
Vânia Guimarães, Rui Castro, Angels Bayés, Carlos Pérez and Daniel Rodriguez-Martin

Introduction • Cueing Strategies for Gait in Parkinson’s Disease • State of the Art: Competitive Analysis • REMPARK Auditory Cueing System (ACS) • Outcomes from Field Trials: Future Considerations • A Step Further in REMPARK: Automatic Drug Administration • Conclusion • References

Chapter 8: Disease Management System (DMS)
Hadas Lewy

Introduction • Disease Management System Application • DMS Functional Organization • Advantages Using the Disease Management System (DMS) • Advantages for the Clinical Team • Advantages for the Patients • Advantages for the Organization • Conclusions, Discussion and Vision • References

Chapter 9: REMPARK System Assessment: Main Results
Albert Sama, J Manuel Moreno, Carlos Pérez, Joan Cabestany, • Angels Bayés and Jordi Rovira

Introduction • Description of Main Communication Flows • Type of Transmitted Information • Security Aspects • Final Deployment and Implementation of the REMPARK Platform • Pilot for the REMPARK System Assessment: Description • Definition of the Pilots’ Objectives and Eligibility Criteria • Design of the Study • Pre-Pilot Conclusions • REMPARK Pilots’ Execution and Obtained Results • Performance of the System • Validity of the ON-OFF Detection Algorithm • The methodology • Validation of the ON-OFF diaries: available data • Results of the ON/OFF state detection • Non-Motor Symptoms Descriptive Analysis • Efficacy and Effectiveness of the Cueing System • Health-Safety of the REMPARK System • Usability and User Satisfaction of the REMPARK System • Summary and Conclusions • References

Chapter 10: Epilogue and Some Conclusions
Roberta Annicchiarico, Angels Bayés and Joan Cabestany

Summary of PD Symptoms and the Influence on QoL • Existing Barriers of PD Management • The Role of the REMPARK System in the Context • Limitations of the REMPARK System • Clinical Applicability of the REMPARK System • As a Concluding Remark • References


About the Editors

About the Editors :

Joan Cabestany holds a Telecommunications Engineer degree (1976) from the Universitat Politècnica de Catalunya (UPC) in Barcelona, Spain. He got his PhD (1982) from the same University, where he is working as a Full-time Professor in the Department of Electronic Engineering.

He has been involved in research and innovation activities as a part of his career. He is the responsible member of theAHA(“Advanced HardwareArchitectures”) research group at UPC, with expertise on reconfigurable hardware, electronic system design, advanced hardware architectures, microelectronics, and VLSI design. One of the main topics of interest has been the practical application of the Artificial Intelligence to the functional improvement of electronic systems.

He is a member of the CETpD Research Center staff structure at UPC since 2005. The activities of CETpD are focused on technological developments applied to the improvement and help people with chronic diseases, like Parkinson Disease and different conditions related with aging.

On behalf of UPC, Prof. Cabestany has been responsible for several EUfunded projects. Among them, the REMPARK project on PD management and the FATE project for the accurate detection of falls in aging people are the two projects, where Prof. Cabestany has been acting as coordinator. He is the co-author for more than 100 research papers and communications to Conferences. Prof. Cabestany is a co-founder of the Sense4Care Company (www.sense4care.com), a Spin-off of the UPC commercializing relevant innovative research results.

Angels Bayés Rusiñol MD is a Doctor in Medicine and Neurology specialist. Her career and research activity has been focused on the study and treatment of Movement Disorders like Parkinson’s Disease (PD) and Tourette syndrome, and on dementias, like Alzheimer’s disease.

She has been the director of the Unit for Movement Disorders and Parkinson of TEKNON Medical Center in Barcelona (Spain) during the last 20 years.

Her main research areas are related to the implementation of complete treatment, complementary therapies, psycho-education, and to try to improve the quality of life of patients suffering from movement disorders. During the last 5 years, she has been cooperating with an engineering team at Universitat Politècnica de Catalunya, in Barcelona, for the development and implementation of technological solutions for the support and management of PD.

She has participated in 39 research projects, with special mention of the EU funded EDUPARK and REMPARK ones. She has authored more than 60 publications, including 6 books, many conferences, communications, and training courses.

Target Audience:

People interested in Parkinson’s disease, disease management, wearing off fluctuations, dyskinesia’s, Freezing of gait, ON/OFF states detection, automatic detection of motor symptoms, wearable sensors, auditory cueing system.


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