Title Atlas of Cilia Bioengineering and Biocomputing
Subtitle (River Publishers Series in Biomedical Engineering)
Author Richard Mayne, Jaap den Toonder
ISBN 9788770220026
List price USD 112.00
Price outside India Available on Request
Original price
Binding Hardbound
No of pages 225
Book size 152 X 235 mm
Publishing year 2018
Original publisher River Publishers (Eurospan Group)
Published in India by .
Exclusive distributors Viva Books Private Limited
Sales territory India, Sri Lanka, Bangladesh, Pakistan, Nepal, .
Status New Arrival
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Cilia are microscopic finger-like cell-surface organelles possessed by a great many eukaryotic organisms, including humans, whose purposes include generating local fluid movements via rhythmic whip-like beating and environmental sensing. Despite intense research efforts since their discovery by van Leeuwenhoek in the 1670’s, several key questions regarding ciliary functions, experimental manipulation and in silico imitation remain unanswered. Major justifications for cilia research lie in their involvement in various forms of human disease (ciliopathies) and their ability to instantiate decentralised, asynchronous sensorial-actuation of adjacent matter through modulation of beating characteristics. Further elucidation of these characteristics, which is a problem requiring the combined expertise of mathematicians, computer scientists, engineers and life scientists, will lead to novel biomedical therapies, creation of `smart’ actuating surfaces for microfluidics/lab-on-chip applications and a greater understanding of fluid mechanics in real-world scenarios.

This lavishly-illustrated anthology presents recent advances in the fields of ciliary investigation, manipulation, emulation, mimesis and modelling from key researchers in their fields: its goal is to explain the state-of-the-art in cilia bioengineering and bio-computation in a uniquely creative, accessible manner, towards encouraging further transdisciplinary work in the field as well as educating a broad spectrum of scientists and lay people.

The volume is split into three distinct but interwoven themes:

  • Biology: Biological preliminaries for the study of cilia; the state-of-the-art in genetic engineering of ciliated cells for biomedical purposes; reprogramming of cilia dynamics in live cells.
  • Engineering: Creation of macro cilia robots for object sorting applications; pneumatic cilia for the optimization of fluid motion; electrostatic, magnetic and MEMS cilia for microfluidic mixing; reviews in artificial cilia fabrication, actuation and flow induction methods.
  • Numerical and computational modelling. Analyses of thin film cilia for `lab on chip’ microfluidic mixing applications; modelling of gel-based artificial cilia towards simulating dynamic behaviors of responsive cilia layers in complex fluids across a wide range of potential applications.


Editor Foreword

List of Contributors

List of Figures

List of Tables

List of Abbreviations

PART I: Biology

Chapter 1: Biological Preliminaries for Cilia Study
Richard Mayne and Gabrielle Wheway

Introduction • Primary Cilia • Motile Cilia • Structure • The Ciliary Beat • References

Chapter 2: Genetic Engineering of Ciliated Cells
Gabrielle Wheway

Introduction • Cell Selection and Growth • Cells with Primary Cilia • Cells with Motile Cilia • Transfection of Cells • RNA Interference • Fluorescent Protein Labeling • Optogenetics • Proximity-Dependent Biotinylation (BioID) • Tandem Affinity Purification (TAP) • Genome Editing Using TALENs, Zn Finger Nucleases, CRISPR/Cas, and Base Editing • References

Chapter 3: Programming Ciliary Object Manipulation
Richard Mayne

Introduction • Sorting by Paramecium Cilia • Reprogramming Paramecium Cilia • References

PART II: Engineering

Chapter 4: Robotic Cilia for Autonomous Parallel Distributed Sorting Platforms
James G. H. Whiting

Introduction • Engineering Sorting Ciliary Platforms • References

Chapter 5: Artificial Pneumatic Cilia
Benjamin Gorissen, Edoardo Milana, Michael De holder and Dominiek Reynaerts

Introduction • Base Actuated Pneumatic Cilia • Body Actuated Pneumatic Cilia • Conclusion References

Chapter 6: Blinking-Vortex Inspired Mixing with Cilia
Nathan Banka and Santosh Devasia

Cilia Actuation Scheme • Experiments and Simulations • Results • References

Chapter 7: Magnetic Thin-film Cilia for Microfluidic Applications
Srinivas Hanasoge, Peter J. Hesketh and Alexander Alexeev

Introduction • Fabrication of Magnetic Cilia • Fluid Transport by An Array of Beating Magnetic Cilia . • Kinematics of Magnetic Cilia • Counter-Clockwise Rotation of Magnetic Field . • Clockwise Rotation of Magnetic Field • Metachronal Motion • Microfluidic Applications of Artificial Cilia • Microfluidic Mixing • Bacteria Capture • Summary • References

Chapter 8: Artificial Cilia: Fabrication, Actuation, and Flow Generation
Jaap M. J. den Toonder, Ye Wang, Shuaizhong Zhang and Patrick Onck

Introduction • References

PART III: Theoretical and Computer Modelling

Chapter 9: Numerical Simulations of Fluid Transport by Magnetically Actuated Artificial Cilia
Syed Khaderi, Jaap M. J. den Toonder and Patrick Onck

Introduction • References

Chapter 10: Modeling Gel-based Artificial Cilia
Olga Kuksenok, Ya Liu and Anna C. Balazs

Introduction • Designing Chemo-responsive Cilial Systems • Methodology: Gel Lattice Spring Model • Self-oscillating Cilia • Photo-responsive Gel-Fiber Systems • Capturing Hydrodynamic Interactions in Complex Fluids • Methodology • Utilizing Oscillating Rods to “Catch and Release
” Targeted Nanoparticles • Artificial Cilia Based on Biological Aptamers • Methodology • Catch and Release with Aptamer-mimicking Cilia • Conclusions • References


About the Editors

About the Editors :

Richard Mayne is a resident Research Fellow in Biocomputing at the University of the West of England (UWE), UK. Having originally qualified and practiced as a Biomedical Scientist, he moved to research and received his PhD in Computer Science in 2016. He specialises in the design and fabrication of biocomputing devices which harness emergence, complexity and cognition in live cells, towards finding new materials and applications for computing technologies, in addition to describing poorly understood natural phenomena in algorithmic terms.

Richard has worked at UWE’s Unconventional Computing Laboratory since 2013 and has participated in a number of projects, including developing a range of heterotic, intracellular and morphological slime mould (Physarum) computers, doing non-Boolean collision-based computation with liposomes and reprogramming ciliary dynamics in live cells.

Jaap den Toonder is full professor and Chair of the Microsystems group at Eindhoven University of Technology. He received his Master’s degree in Applied Mathematics in 1991 (cum laude), and his PhD degree (cum laude) in 1996, both from Delft University of Technology.

In 1995, he joined Philips Research Laboratories in Eindhoven, The Netherlands, where he worked on a wide variety of applications. In 2008, he became Chief Technologist, leading the R&D programs on (micro-)fluidics and materials science and engineering. Next to his main job at Philips, he was a part-time professor of Microfluidics Technology at Eindhoven University of Technology between 2004 and 2013. Jaap den Toonder’s group focuses its research on the investigation and development of novel microsystems design approaches and out-of-cleanroom fabrication technologies. The application focus is on microfluidic chips, biomedical microdevices, organs-on-chips, and soft microrobotics. The group’s research approaches are often biologically inspired, translating principles from nature into technological innovations. Jaap den Toonder has (co-)authored over 100 scientific papers, as well as over 40 patents, and he has given over 50 invited lectures at international conferences.

Target Audience:

People interested in Microfluidics, Genetic Engineering, MEMS, Numerical Simulation, Fluid Mechanics, Parallel Actuation, Biocomputing, Unconventional Computing


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