Title Translation Mechanisms and Control
Author Michael B. Mathews, Nahum Sonenberg, John W.B. Hershey
ISBN 9781621821861
List price USD 135.00
Price outside India Available on Request
Original price
Binding Hardbound
No of pages 0
Book size 184 X 267 mm
Publishing year 2018
Original publisher Cold Spring Harbor Laboratory Press
Published in India by .
Exclusive distributors Viva Books Private Limited
Sales territory India, Sri Lanka, Bangladesh, Pakistan, Nepal, .
Status New Arrival
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Translation is the process by which cells synthesize proteins. During the process, molecular machines called ribosomes use messenger RNA molecules that relay the genetic code from DNA to direct assembly of the amino acid building blocks that make up proteins. This is all tightly controlled to ensure that the correct proteins are synthesized at the appropriate time and in the quantities needed by the cell. Aberrant translation causes significant problems for cells and contributes to cancer and various neurological disorders (e.g., autism).

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines our current understanding of all aspects of protein synthesis and its control. The contributors describe recent insights into the fundamental steps in translation (initiation, elongation, termination, and ribosome recycling) based on high-resolution structures of the translational machinery. The signaling pathways and targets of translational control (e.g., initiation factors, mRNAs, and ribosomes) are discussed, as are the roles of riboswitches, processing bodies (P-bodies), stress granules, and various classes of RNAs (e.g., circular RNAs). Methods to study translation dynamics, including ribosome profiling, kinetic assays, and single-molecule and single-cell fluorescence imaging, are also covered.

In addition, the authors examine translational control during early embryo development, stem cell differentiation, and memory formation. The deregulation of translation in cancer and neurological disorders, as well as the development of small molecules that target translation for therapeutic purposes, is also discussed. This volume is therefore an essential reference not only for cell and molecular biologists but also for cancer biologists and others who investigate human diseases associated with dysregulation of translation.



Principles of Translational Control
John W.B. Hershey, Nahum Sonenberg, and Michael B. Mathews

Protein Synthesis and Translational Control: A Historical Perspective
Soroush Tahmasebi, Nahum Sonenberg, John W.B. Hershey, and Michael B. Mathews

Protein Synthesis Initiation in Eukaryotic Cells
William C. Merrick and Graham D. Pavitt

Translation Elongation and Recoding in Eukaryotes
Thomas E. Dever, Jonathan D. Dinman, and Rachel Green

Translation Termination and Ribosome Recycling in Eukaryotes
Christopher U.T. Hellen

Translation in Prokaryotes
Marina V. Rodnina

New Insights into Ribosome Structure and Function
Amy Jobe, Zheng Liu, Cristina Gutierrez-Vargas, and Joachim Frank

Ribosome Profiling: Global Views of Translation
Nicholas T. Ingolia, Jeffrey A. Hussmann, and Jonathan S. Weissman

Toward a Kinetic Understanding of Eukaryotic Translation
Masaaki Sokabe and Christopher S. Fraser

Single-Molecule Fluorescence Applied to Translation
Arjun Prabhakar, Elisabetta Viani Puglisi, and Joseph D. Puglisi

Fluorescence Imaging Methods to Investigate Translation in Single Cells
Jeetayu Biswas, Yang Liu, Robert H. Singer, and Bin Wu

The Epitranscriptome in Translation Regulation
Eyal Peer, Sharon Moshitch-Moshkovitz, Gideon Rechavi, and Dan Dominissini

Roles of Long Noncoding RNAs and Circular RNAs in Translation
Marina Chekulaeva and Nikolaus Rajewsky

Noncanonical Translation Initiation in Eukaryotes
Thaddaeus Kwan and Sunnie R. Thompson

Repeat-Associated Non-ATG Translation in Neurological Diseases
Tao Zu, Amrutha Pattamatta, and Laura P.W. Ranum

The Interplay between the RNA Decay and Translation Machinery in Eukaryotes
Adam M. Heck and Jeffrey Wilusz

Nonsense-Mediated mRNA Decay Begins Where Translation Ends
Evangelos D. Karousis and Oliver Mühlemann

Riboswitches and Translation Control
Ronald R. Breaker

Mechanistic Insights into MicroRNA-Mediated Gene Silencing
Thomas F. Duchaine and Marc R. Fabian

Stress Granules and Processing Bodies in Translational Control
Pavel Ivanov, Nancy Kedersha, and Paul Anderson

Role of eIF2a Kinases in Translational Control and Adaptation to Cellular Stress
Ronald C. Wek

Phosphorylation and Signal Transduction Pathways in Translational Control
Christopher G. Proud

Translational Control in Cancer
Nathaniel Robichaud, Nahum Sonenberg, Davide Ruggero, and Robert J. Schneider

Translational Control during Developmental Transitions
Felipe Karam Teixeira and Ruth Lehmann

Translational Control in the Brain in Health and Disease
Wayne S. Sossin and Mauro Costa-Mattioli

Translational Control in Virus-Infected Cells
Noam Stern-Ginossar, Sunnie R. Thompson, Michael B. Mathews, and Ian Mohr

Therapeutic Opportunities in Eukaryotic Translation
Jennifer Chu and Jerry Pelletier


Target Audience:

An essential reference not only for cell and molecular biologists but also for cancer biologists and others who investigate human diseases associated with dysregulation of translation.

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