Title Recent Trends in Nanomedicine and Tissue Engineering
Subtitle River Publishers Series in Research and Business Chronicles: Biotechnology and Medicine
Author Jince Thomas, Sabu Thomas, Jiya Jose, Nandakumar Kalarikkal
ISBN 9788793609167
List price USD 106.00
Price outside India Available on Request
Original price
Binding Hardbound
No of pages 400
Book size 153 x 235 mm
Publishing year 2017
Original publisher River Publishers (Eurospan Group)
Published in India by .
Exclusive distributors Viva Books Private Limited
Sales territory India, Sri Lanka, Bangladesh, Pakistan, Nepal, .
Status New Arrival
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Recent trends in Nanomedicine and Tissue Engineering covers numerous recent technological and research accomplishments in the area of Nanomedicine and Tissue Engineering. The introduction of nanomaterials and nanotechnology have led to crucial advancements in the fields of nanomedicine and tissue engineering, as well as cancer therapies and drug delivery systems. 

The book follows recent trends in drug delivery systems, wound healing fields, cancer therapies, protection of teeth and also other health care systems. 

Technical topics discussed include:

  • Nanorobots
  • Tissue engineering
  • Gene therapy
  • Drug delivery
  • Nanomotors
  • Nanogels





List of Contributors

List of Figures

List of Tables

List of Abbreviations

Chapter1: Nanomedicine and Nanotechnology: State of Art, New Challenges and Opportunities (Jince Thomas, Jiji Abraham and Sabu Thomas) • Introduction • Scope • Drug Delivery • Tissue Engineering and Nanoscaffolding and Wound Healing • Diagnostics • History • Commercial Significance and Current Challenges • References

Chapter 2: Novel Approaches to Nanomedicine and Nanotechnology (Apparao Gudimalla, Raghvendra K. Mishra and Prerna Arora) • Introduction • Nanomedicine • History of Nanomedicine • Present Facing Challenges; Translation of Nanotechnology to Nanomedicine • Nanoparticles in Cancer Therapy • Liposomes • The Solid Lipid Nanoparticles • Carbon Nanotubes • Carbon Nanotubes in Cancer Treatment • Single-walled carbon nanotubes in the treatment of cancer • Multi-walled carbon nanotubes in the treatment of cancer • Drug Delivery • The Applications of Nanoparticles in Drug Delivery • Nanoparticles Anti-Oxidative Role in Diabetes • Nanomedicine in Management of Diabetes • Nanorobotics • Types of Nanorobots • In surgery • Drug delivery • In diagnosis Applications of Nanorobots in Medicine • Advantages of Nanorobots • Disadvantages of Nanorobots • Future Development of Nanomedicine • Conclusion • Acknowledgment • References

Chapter 3: Chitosan and Its Derivatives as a Potential Nanobiomaterial: Drug Delivery and Biomedical Application (Abhay Raizaday, Hemant K. S. Yadav and Susmitha Kasina) • History • Chemistry • Advantages • Disadvantages • Properties of Chitosan • Physicochemical • Crystalline structure • Degree of N-Acetylation • Molecular weight • Solubility • Viscosity • Biological Properties • Mucoadhesive properties • Permeation enhancing properties • Haemostatic activity • Antimicrobial activity • Analgesic effect • Biodegradability • Extraction of Chitosan • Preparation of Chitosan and Water Soluble Chitosan • Extraction of Chitin from the Beetle • Extraction of collagen from squid • Extraction of chitosan from fungi cell wall • Extraction of Chitin, Chitosan, from Shrimp by biological method • Chitosan Derivatives • Carboxymethylchitosan • Mono-Carboxymethylated Chitosan • N-Succinyl Chitosan • N-Acetylated Chitosan • N-Trimethyl Chitosan • N-Trimethylchitosan Chloride • Succinate and Chitosan Phthalate • Amphiphilic Chitosan Derivatives • Graft-Copolymerization of Chitosan • Thiolated Chitosan Conjugate • Cyclodextrin (CD)-Chitosan Derivative • Applications of Chitosan as Nanobiomaterial • Mucoadhesive Property • Permeation Enhancement • Wound Healing • Gene Delivery • Vaccine Delivery • Conclusion • References

Chapter 4: Design and Characterization of Lipid Mediated Nanoparticles Containing an Anti-Psychotic Drug for Enhanced Bio-Availability (Jawahar Natarajan, Gowtham Reddy Naredla and Veera Venkata Satyanarayana Reddy Karri)Introduction • Experimental Part • Preformulation Studies • Solubility studies • Compatibility study • Development of calibration curve • Partition coefficient studies • Preparation of Solid Lipid Nanoparticles (SLN) by Microemulsion Technique • Optimization of lipid quantity • Study on the effect of formulation process variables • Preparation of drug loaded batches • Evaluation of Solid Lipid Nanoparticles • Particle size, zeta potential and polydispersity index • Entrapment efficiency and drug loading • Differential scanning calorimetry • In vitro Release Studies • In vivo Oral Bioavailability Studies • Bioanalytical Method Development and Analysis • Chromatographic conditions • Preparation of olanzapine standard stock solution Standard stock solution of IS (Internal standard) • Preparation of analytical calibration curve solutions • Preparation of blank plasma • Preparation of bio-analytical calibration curve samples • Preparation of plasma samples • Method of analysis •  Results and Discussion • Preformulation Studies • Solubility studies • Compatibility Studies • Development of calibration curve • Partition coefficient studies • Effect of Formulation Process Variables • Evaluation of Solid Lipid Nanoparticles • Zeta potential • Polydispersity • Entrapment efficiency and drug loading • Differential scanning colorimetry • In vitro release studies • Release kinetics • Bioanalytical Method Development and Analysis • Conclusion • References

Chapter 5: Nanogels: The Emerging Carrier in Drug Delivery System (Prashant Sahu, Sanwresh Sau, Arun K. Iyer and Sushil K. Kashaw) • Introduction • Properties of Nanogels • Good Drug Loading Capacity • Solubility • Colloidal Stability • Particle Size • Biocompatibility and Degradability • Electro Mobility • Non-Immunologic Response • Others • Classification of Nanogels • Responsive Type • Non-responsive nanogels • Stimuli-responsive nanogels • Linkage Type • Physical cross-linked gels • Liposomes modified nanogels • Micellar nanogels • Hybrid nanogel • Chemically cross-linked nanogels • Method of Preparation of Nanogel • Photolithographic Technique • Micro-Moulding Method • Bi-Polymers Synthesis Technique • Water in Oil (W/O) Heterogeneous Emulsion Method • Inverse Mini Emulsion Method • Reverse Micelliar Method • Membrane Emulsification Method • Heterogeneous Free Radical Polymerization • Inverse micro emulsion • Inverse mini-emulsion polymerization • Precipitation polymerization • Dispersion polymerization • Heterogeneous controlled/living radical polymerization • Conversion of Macrogels to Nanogels • Chemical Cross-Linking Method • Characterization of Nanogel • Morphological Analysis • Scanning Electron Microscopy (SEM) • Transmission Electron Microscopy (TEM) • Size and Shape • Viscosity • Phase Behaviour • Optical Transparency • Spectroscopic Analysis • pH • Routes of Administration of Nanogel • Parenteral Drug Delivery System • Oral Drug Delivery System • Transdermal Drug Delivery • Ocular Drug Delivery System • Pulmonary or Intranasal Drug Delivery System • Application of Nanogels • Nano-Sized Drug Delivery System • Peptide and Protein Delivery •  Vaccine Delivery • Gene Delivery • Antiviral Nanogel Delivery • Antifungal Nanogel Delivery • In Autoimmune Diseases • Ophthalmic Delivery • Diabetes • Coagulating Agent • Anti-Inflammatory Agent • Disadvantages of Nanogel • Conclusion • References

Chapter 6: Fe, Co Based Bio-Magnetic Nanoparticles (BMNPs): Synthesis, Characterization, and Biomedical Application
(Amirsadegh Rezazadeh Nochehdehi, Sabu Thomas, Minoo Sadri,
S. M. Mehdi Hadavi, Yves Grohens, Nandakumar Kalarikkal and
Neerish Revaprasdu) •
Introduction • Magnetic Properties • Magnetic Nanoparticles • Iron and iron oxide nanoparticles • Cobalt-based nanoparticles • Synthesis and Characterization of Magnetic Nanoparticles (MNPs) • Iron Oxide (Fe304) Nanoparticles (ION) • Cobalt-Based (FeCo) Nanoparticles (CBN) • Synthesis and Characterization of Core/Shell Magnetic Nanoparticles (CS-MNPs) • Iron Oxide Core/Shell Nanoparticles (IOCSN) • Fe304 @Ag core/shell nanoparticles • Fe304@Chitosan core/shell nanoparticles • Cobalt-Based Core/Shell Nanoparticles (CBCSN) • FeCo@C core/shell nanoparticles • FeCo@PEG core/shell nanoparticles • Biomedical Application of Magnetic Nanoparticles (MNPs) • Bioimaging Application of MNPs • Controlled Drug Delivery (TDD) • Applications of MNPs • Cancer Diagnosis and Treatment via Hyperthermia Method (CDT) Using MNPs • Conclusion • Acknowledgement • References

Chapter 7: Comparative Study on Cytotoxic and Bactericidal Effect of Nanoscale Zero Valent Iron Synthesized through Chemical and Biological Methods (Sharath R., Harish B. G., Chandraprabha M. N., Samrat K., Nagaraju Kottam, Hari Krishna R., Rakesh G. Kashyap and
Muktha H.) •
Introduction • Materials and Methods • Materials • Methods • Synthesis of nanoscale Zero Valent Iron (nZVI) by chemical and biological methods • Characterization Studies • Screening of Bactericidal and Cytotoxic Activity • Results and Discussion • Synthesis of Nanoscale Zero Valent Iron (nZVI) by Chemical and Biological Methods • Characterization of nZVI Particles • Screening of Bactericidal and Cytotoxic Activity • Conclusion • References


Chapter 8: Simulation Studies of Nanomotors Based on Carbon Nanotubes for Nanodelivery Systems (Sunita Negi) • Introduction • Nanomotor • Protein Structure • Simulation Method • Summary and Future Scope • References

Chapter 9: Synthesis and Characterization of Lipid-Conjugated Carbon Nanotubes for Targeted Drug Delivery to Human Breast Cancer Cells (Jawahar Natarajan, Surendra Ekkuluri and Veera Venkata Satyanarayana Reddy Karri) • Introduction • Experimental Part • Preformulation Studies • Solubility studies • Standard calibration curve • Compatibility study • Preparation of Carbon Nanotubes • Study on the effect of formulation process variables • Purification, Cutting, and Oxidation of CNTs • Particle Size, Zeta Potential, and Polydispersity Index (PDI) • Surface Morphology by Scanning Electron Microscopy (SEM) • Preparation of CNTs-RH-Folic Acid (CNTs-RH-FA) • Characterization of CNT-RH-FA • Size distribution and zeta potential • Scanning Electron Microscopy (SEM) • Determination of Loading Efficiency • In Vitro Drug-Release Studies • Determination of Mitochondrial Synthesis by MTT Assay • Results and Discussion • Preformulation Studies • Solubility studies • Development of calibration curve • Crystallinity study by using DSC • Compatibility studies using FT-IR • Preparation of Carbon Nanotubes • Particle Size Distribution and Zeta Potential • Scanning Electron Microscopy (SEM) • Drug Loading Efficiency • In Vitro Drug-Release Studies • In Vitro Cytotoxicity Studies • Conclusion • References

Chapter 10: Phytosynthesis of Silver Nanoparticles and Its Potent Antimicrobial Efficacy (Soumya Soman and Joseph George Ray) • Introduction • Advantages of Phytosynthesis • Major Objective • Phytosynthesis of AgNPs • Extracellular Synthesis of AgNPs Using Plant Extracts: A Few Case Studies • Effect of Environment Parameters Influencing Phytosynthesis • Probable Mechanism for AgNP Formation • Importance of Antibacterial Activity of Phytosynthesized AgNPs • Antibacterial Activity of Phytosynthesized AgNPs: Case Studies • Mechanism of Action of AgNPs • Different Postulates of Mechanism of AgNPs Toxicity to Bacteria • Antibacterial Applications of AgNPs • Conclusion • References

Chapter 11: Recreation of Turmeric Matrix with Enhanced Curcuminoids­—Enhances the Bioavailability and Bioefficacy
Augustine Amalraj and Sreeraj Gopi) • Introduction • Discovery of Curcumin • Isolation of Curcumin • Physical, Chemical, and Molecular Properties of Curcuminoids • Experimental Part • Preparation Method of CureitTM • Analytical Method for Analysis of Plasma Curcumin Level in CureitTM and Standard Curcumin • Statistical Analysis • Results and Discussion • Chemical Analysis of CureitTMCharacterization of CureitTMNMR studies of cureitTMFT-IR studies of cureitTM XRD studies of cureitTM TGA/DTA studies of cureitTM SEM analysis of cureitTM I-V studies of cureitTMBioavailability and Bioefficacy Studies of CureitTM • Comparative Oral Bioavailability Study of CureitTM with Standard Curcumin • Recent Studies on the CureitTMConclusions • References

Chapter 12: The Good Tooth, The Bad Influence of Aciduric Germs and The Ugly Stench of Decay (T. Jesse Joel and P. W. Ramteke) • The Good, The Bad, and The Ugly Microbe–Streptococcus Mutans • Introduction • Streptococcus mutans: Isolation and identification • Habitat and nature of source • Taxonomy • Dangerous Etiology or a Farce • Anaerobiosis • Pathogenecity • Virulence • Transmissibility • Risk factors • Other Organisms Associated with Caries • References

Chapter 13: Therapeutic Angiogenesis in Cardiovascular Diseases, Tissue Engineering, and Wound Healing (K. R. Rakhimol,
Robin Augustine, Sabu Thomas
and Nandakumar Kalarikkal)Introduction • Therapeutic Angiogenesis: Concept, Approaches, and Applications • Approaches • Direct VEGF administration • Cell-based therapy • Regulation at genomic/molecular level • Hypoxia-induced angiogenesis • Applications of Therapeutic Angiogenesis • Wound healing • Bone development • Cardiac diseases • Growth Factors Needed for Angiogenesis • Fibroblast Growth Factor • Vascular Endothelial Growth Factor • Platelet-Derived Growth Factor • Reactive Oxygen Species-Dependent Angiogenesis • Metal Nanoparticle-Based Angiogenesis • Stimulating Angiogenesis in Scaffolds by Therapeutic Angiogenesis • Challenges and Risks • Conclusion • References

Chapter 14: Toxicity of Nanomaterials Used in Nanomedicine (Parvathy Prasad, Sunija Sukumaran, Nitheesha Shaji, V.K. Yadunath,
Jiya Jose, Nandakumar Kalarikkal
and Sabu Thomas)Introduction • Nanomedicine • Nanomaterials Used for Nanomedicine • Toxicokinetics of Nanoparticles • Toxicity of Nanoparticles • Effect of Nanoparticles in Some Aquatic Organisms • Discussion • Conclusion • References


About the Editors


About the Editors :

Jince Thomas, Mahatma Gandhi University, Kerala, India.
Sabu Thomas, Mahatma Gandhi University, Kerala, India.
Jiya Jose, Mahatma Gandhi University, Kerala, India.
Nandakumar Kalarikkal, Mahatma Gandhi University, Kerala, India.

Target Audience:

People working in nanomedicine, tissue engineering and cancer therapies.


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