Title Cell Death, 2/e
Subtitle Apoptosis and Other Means to an End
Author Douglas R. Green
ISBN 9781621822141
List price USD 46.00
Price outside India Available on Request
Original price
Binding Paperback
No of pages 278
Book size 165 x 229 mm
Publishing year 2018
Original publisher Cold Spring Harbor Laboratory Press
Published in India by .
Exclusive distributors Viva Books Private Limited
Sales territory India, Sri Lanka, Bangladesh, Pakistan, Nepal, .
Status New Arrival
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Description:

A million cells in our bodies die every second—they commit suicide by activating a process called apoptosis or other forms of programmed cell death. These mechanisms are essential for survival of the body as a whole and play critical roles in various developmental processes, the immune system, and cancer.

In this second edition of Douglas Green’s essential book on cell death, Green retains the bottom-up approach of the first edition, starting with the enzymes that carry out the execution (caspases) and their cellular targets before examining the machinery that connects them to signals that cause cell death. He also describes the roles of cell death in development, neuronal selection, and the development of self-tolerance in the immune system, as well as how the body uses cell death to defend against cancer.

The new edition is fully updated to cover the many recent advances in our understanding of the death machinery and signals that control cell death. These include the mechanisms regulating necroptosis, mitophagy, and newly identified processes, such as ferroptosis. The book will thus be of great interest to researchers actively working in the field, as well as biologists and undergraduates encountering the topic for the first time.


Contents:

Foreword from the First Edition by Martin Raff

Preface from the First Edition

Foreword by Shigekazu Nagata

Preface

Introduction

Chapter 1: A Matter of Life and Death

Chapter 2: Caspases and Their Substrates

Chapter 3: Caspase Activation and Inhibition

Chapter 4: The Mitochondrial Pathway of Apoptosis, Part I: MOMP and Beyond

Chapter 5: The Mitochondrial Pathway of Apoptosis, Part II: the BCL-2 Protein Family

Chapter 6: The Death Receptor Pathway of Apoptosis

Chapter 7: Inflammasomes and Other Caspase-Activation Platforms

Chapter 8: Nonapoptotic Cell Death Pathways

Chapter 9: The Burial: Clearance and Consequences

Chapter 10: Cell Death in Development

Chapter 11: Cell Death and Cancer

Chapter 12: The Future of Death

Figure Credits

Additional Reading

Index


Target Audience:

This book will be of great interest to researchers actively working in the field, as well as biologists and undergraduates encountering the topic for the first time.

 
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