Title Neural Control of Blood Pressure and Body Temperature During Heat Stress
Author Zachary J. Schlader, Nisha Charkoudian
ISBN 9781615047789
List price USD 44.95
Price outside India Available on Request
Original price
Binding Paperback
No of pages 106
Book size 153 x 229 mm
Publishing year 2018
Original publisher Morgan & Claypool Publishers (Eurospan Publishers)
Published in India by .
Exclusive distributors Viva Books Private Limited
Sales territory India, Sri Lanka, Bangladesh, Pakistan, Nepal, .
Status New Arrival
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Environmental heat stress is associated with a marked decrease in orthostatic tolerance (OT), which is defined as the ability to stand or sit upright without symptoms of dizziness, lightheadedness, presyncope, or fainting. In most healthy humans, the autonomic nervous system makes rapid and balanced adjustments to heart rate and peripheral blood flow, such that most people are able to stand up “successfully” most of the time, in most environments. The goal of this book is to discuss various aspects of the sympathetic neural response to heat stress, how the sympathetic nervous system coordinates the successful integrative physiological response to orthostasis, and what happens when it encounters both challenges simultaneously. We include overviews of mechanisms of thermoregulation and blood pressure regulation in humans, with particular focus on control of cardiac output and neurovascular control mechanisms during heat stress. We discuss the implications that these changes have for distribution of peripheral blood flow and, in particular, for blood flow to the cerebral circulation. The added stressor of dehydration is also discussed, as it so often goes hand in hand with heat stress. We end with a brief presentation of countermeasures against the decreases in OT with heat stress.


Chapter 1: Introduction and Overview

Chapter 2: Heat Stress and Orthostatic Tolerance • Heat stress defined • Heat stress impairs orthostatic tolerance

Chapter 3: Autonomic Control of Cardiovascular Function • Measuring the activity of the autonomic nervous system in humans

Chapter 4: Thermoregulation During Heat Stress • Human temperature regulation • Sensors of body temperature • Central thermosensors • Peripheral thermosensors • Central nervous system integration • Heat balance and thermoregulatory responses during heat stress • Skin blood flow—cutaneous vasodilation • Sweating

Chapter 5: The Arterial Baroreflexes in Humans • Measurement approaches

Chapter 6: Cardiac Output and Blood Flow Redistribution During Heat Stress • Cardiac output during heat stress • Heart rate • Stroke volume • The Frank-Starling relationship during heat stress • Cardiac contractility during heat stress • Cardiac output redistribution during heat stress • Splanchnic and renal blood flow • Muscle blood flow

Chapter 7: Neurovascular Control During Heat Stress • Venoarteriolar response

Chapter 8: Control of Cerebral Perfusion During Heat Stress • Heat stress decreases brain blood flow • Mechanisms of heat stress-induced reductions in cerebral perfusion • Perfusion pressure • Partial pressure of arterial carbon dioxide • Sympathetic activation • Regional cerebral perfusion during heat stress • Cerebral perfusion and orthostatic tolerance during heat stress

Chapter 9: Effects of Dehydration on Autonomic and Cardiovascular Responses to Heat Stress

Chapter 10: Countermeasures for Improving Orthostatic Tolerance During Heat Stress

Chapter 11: Summary and Conclusions

Author Biographies

About the Authors:

Zachary Schlader received his Ph.D. in Sport and Exercise Science in 2011 from the Massey University (New Zealand). He subsequently completed a postdoctoral fellowship at the Institute for Exercise and Environmental Medicine at the University of Texas Southwestern Medical Center and Texas Health Presbyterian Hospital Dallas, which is located in Dallas, TX. In 2014, he joined the faculty of the Department of Exercise and Nutrition Sciences at the University at Buffalo (Buffalo, NY). He is a Fellow of the American College of Sports Medicine and currently serves on the editorial board for the American Journal of Physiology: Integrative, Regulatory, and Comparative Physiology. His research is focused on understanding the implications of thermal stress on integrative physiology in healthy and “at risk” (e.g., manual laborers, older adults, various disease states, etc.) populations. To date, his work has focused largely on the autonomic and cardiovascular responses elicited by changes in body temperature. The overall goal is to elucidate the underlying mechanisms and identify ways to mitigate the adverse effects of thermal stress.

Nisha Charkoudian received her Ph.D. degree in Physiology in 1999 from the University of Texas Health Science Center at San Antonio. She completed two post-doctoral fellowships, the first (1999–2000) at the University of Angers in Angers, France, and the second (2000–2003) at the Mayo Clinic in Rochester, MN. She joined the faculty of the Department of Physiology and Biomedical Engineering at Mayo as Assistant Professor in 2003 and was promoted to Associate Professor of Physiology in 2008. She moved to the Boston area in 2011, where she joined the scientific staff of the U.S. Army Research Institute of Environmental Medicine. She serves as Associate Editor of the American Journal of Physiology: Heart and Circulatory Physiology and Medicine and Science in Sports and Exercise and is a member of the editorial boards of several other physiology journals, including the Journal of Applied Physiology. Her research is focused on the regulation of body temperature and blood pressure in humans. The main goals of her work are to increase understanding of how the sympathetic nervous system responds to changes in environment, blood volume, hormone status, and other challenges as it works to balance the competing demands of maintaining blood pressure, blood flow, and body temperature across the lifespan.

Target Audience:

This book is intended for people interested in Physiology.


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