Title Neural Control of Renal Function, 2/e
Subtitle Colloquium Lectures on Integrated System Physiology: From Molecule to Function to Disease
Author Ulla C. Kopp
ISBN 9781615047758
List price USD 49.95
Price outside India Available on Request
Original price
Binding Paperback
No of pages 122
Book size 153 x 229 mm
Publishing year 2018
Original publisher Morgan & Claypool Publishers (Eurospan Group)
Published in India by .
Exclusive distributors Viva Books Private Limited
Sales territory India, Sri Lanka, Bangladesh, Pakistan, Nepal, .
Status New Arrival
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The neural control of the kidney is one of the important mechanisms contributing to the physiological control of renal function. The kidney is densely innervated by sympathetic nerves. Increases in renal sympathetic nerve activity decrease renal blood flow and urinary sodium excretion and increase renin secretion rate. Thus changes in efferent renal sympathetic nerve activity contribute importantly to the homeostatic regulation of arterial pressure and sodium balance. The kidney is also innervated by afferent renal sensory nerves, activation of which decreases efferent renal sympathetic nerve activity, thereby providing a mechanism to minimize sodium retention. Importantly in pathological conditions, there is now considerable evidence for increased renal sympathetic nervous activity contributing to a variety of cardiovascular diseases, including hypertension, heart failure and renal failure.

This book provides a comprehensive overview of efferent renal sympathetic nerves and afferent renal sensory nerves in physiological and pathophysiological states. Originally published in 2011, this updated and revised 2nd edition provides more extensive coverage of the role of the renal nerves in pathophysiology, which has been an area of renewed interest since the development of the renal denervation technique in humans.




Part I: Efferent Renal Sympathetic Nerves

Chapter 1: Introduction

Chapter 2: Neuroanatomy • Neural Pathways • Intrarenal Distribution of Efferent Renal Sympathetic Nerves • Characterstics of the of Efferent Renal Sympathetic Nerves Signals Neurotransmitters • Adrenoceptors • Angiotension II, Nitric Oxide, and Reactive Oxygen Species

Chapter 3: Neural Control of Renal Hemodynamics • Measurement of Renal Blood Flow • Renal Denervation • Increases in Renal Sympathetic Nerve Activity • Adrenoceptors

Chapter 4: Neural Control of Renal Tubular Function • Renal Depression • Increases in Renal Sympathetic Nerve Activity • Direct Activation of the Renal Nerves • Reflex-Mediated Increases and Decreases in the Activation of the Renal Nerves • Adrenoceptors • Angiotenism

Chapter 5: Neural Control of Renin Secretion Rate • Increases in Efferent Renal Sympathetic Nerve Activity • Interaction Between Neural and Non-Neural Mechanisms for Renin Secretion • Adrenoceptors

Part II: Afferent Renal Sensory Nerves

Chapter 6: Introduction

Chapter 7: Neuroanatomy • Kidney • Renal Sensory Receptors • Projection to the Central Nervous System

Chapter 8: Renorenal Reflexes • Activation of Afferent Renal Sensory Nerves by Physiological Stimuli • Selective Afferent Renal Denervation • Afferent Renal Reinnervation • Interaction Between Efferent and Afferent Renal Nerve Activity

Chapter 9: Mechanisms Involved in the Activation of Afferent Renal Sensory Nerves • Substance P • Mechanisms Contributing to the Release of Substance P from Renal Pelvic Sensory Nerves • PGE2 • Bradykinin • Angiotensis II • Endothelin

Part III: Pathophysiological States

Chapter 10: Efferent Renal Sympathetic and Afferent Renal Nerves • Hypertension • Renal Failure • Heart Failure

Chapter 11: Conclusions


Author Biography

About the Author:

Ulla C. Kopp is Professor Emerita of Internal Medicine/Nephrology and Pharmacology at the University of Iowa Carver College of Medicine, Iowa City, Iowa. She received her Ph.D. in Pharmacology from the University of Gothenburg, Sweden, and her research interests include renorenal reflexes in normotension and hypertension.|

About the Series Editor:

Joey P. Granger, Ph.D., is the Billy S. Guyton Distinguished Professor, Professor of Physiology and Medicine, Director of the Center for Excellence in Cardiovascular-Renal Research, and Dean of the School of Graduate Studies in the Health Sciences at the University of Mississippi Medical Center in Jackson, MS. He earned his doctorate from the University of Mississippi School of Medicine in 1983.

Dr. Granger served as President of the American Physiological Society and is an Associate Editor for Hypertension. He has also served as the Editor of the Council for High Blood Pressure Newsletter and an Associate Editor for News in Physiological Sciences and American Journal of Physiology. He has served as a member of Editorial Boards of American Journal of Hypertension, American Journal of Physiology-Renal, American Journal of Physiology: Regulatory and Integrative Physiology, Journal of CardioMetabolic Syndrome and the Journal of the American Society of Hypertension.

D. Neil Granger, Ph.D., is Boyd Professor and Head of the Department of Molecular and Cellular Physiology at the LSU Health Sciences Center in Shreveport, Louisiana.

His current research is focused on the role of the microcirculation in acute and chronic inflammation, and how risk factors for cardiovascular disease influence microvascular function. Granger has served on the editorial boards of the Heart & Circulation, GI & Liver, and Cell sections of the American Journal of Physiology, as well as Circulation Research, Microcirculation, Shock, Pathophysiology, Free Radical Biology & Medicine, Lymphatic Research and Biology, and Nitric Oxide Biology & Chemistry. He was Editor-in-Chief of Microcirculation and an Associate Editor of the American Journal of Physiology: GI & Liver Physiology.

Target Audience:

This book is intended for people interested in Biology and Physiology.


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