Title Handbook of Stem Cell Transplantation and Cellular Therapy Management
Subtitle
Author Edwin P. Alyea III, Vincent T. Ho, Brett E. Glotzbecker, Prashant Nageshwar
ISBN 9780826139931
List price USD 75.00
Price outside India Available on Request
Original price
Binding Paperback
No of pages 350
Book size 127 x 203 mm
Publishing year 2021
Original publisher Demos Medical Publishing
Published in India by .
Exclusive distributors Viva Books Private Limited
Sales territory Bangladesh, India, Pakistan, Sri Lanka
Status New Arrival
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Description:

Handbook of Stem Cell Transplantation and Cellular Therapy Management provides an evidence-based practical guide for clinicians and practitioners who treat cancer patients with these challenging and innovative techniques. The handbook begins with chapters on autologous transplantation for myeloma and lymphoma and allogenic transplantation for leukemia, lymphoma, and myelodysplastic syndrome. Further chapters cover the standards of care for managing adverse events related to acute graft-versus-host disease, chronic graft-versus-host disease, infections of bacterial, fungal, and viral nature, lymphoproliferative disease, pulmonary complications, renal complications, and more clinical issues. Concluding chapters address new CAR T-cell therapies, including their mechanisms of action, indications, and unique associated toxicities, in addition to a chapter dedicated to biostatistics and clinical trials. Throughout the book, extensive tables, flow diagrams, and other figures highlight, simplify, and illustrate key concepts.

Written by experienced clinicians at the world-renowned Dana Farber Cancer Center and Harvard Medical School in Boston as well as leading experts at other institutions, this stem cell transplantation handbook combines the clinical knowledge, expertise and practical application of these potential life-saving cell therapies in one quick, point-of-care reference. With real-world clinical vignettes interwoven among the chapters, this handbook is an essential resource for anyone managing patients being treated with stem cell transplantation or cellular therapies.

 

Key Features:

  • Provides latest insights and recommendations for managing challenging treatment complications and adverse events
  • Consolidates key information such as diagnosis criteria, disease staging, common complications, and more using detailed tables and diagrams
  • Shares real-world clinical vignette examples, which provide insight into clinical assessment, treatment, and management
  • Emphasizes patient management and best practices
  • Discusses short- and long-term risks for stem cell transplantation and cellular therapy


Contents:

Contributors

Preface

Chapter 1. Introduction to Hematopoietic Stem Cell Transplantation and Cellular Therapy (Rushdia Yusuf and Edwin P. Alyea III) • Allogeneic and Autologous Transplants • Classification of Allogeneic Transplants • Complications of Allogeneic Transplants • Conclusion • References

Chapter 2. Autologous and Allogeneic Transplantation for Lymphoma (Austin Kim and Eric D. Jacobsen) • I. Autologous Stem Cell Transplantation (Austin Kim) • Classic HL • B-Cell NHL • T-Cell NHL • References • ll. Allogeneic Stem Cell Transplantation (Eric D. Jacobsen) • B-Cell NHL • Hodgkin’s Lymphoma • Peripheral T-Cell Lymphoma • AlloSCT in Less Common PTCL Subtypes • T-Cell Prolymphocytic Leukemia (T-PLL) • Adult T-Cell Leukemia Lymphoma (ATLL) • Cutaneous T-Cell Lymphoma (CTCL) • Conclusion • References • Resources

Chapter 3. Autologous Transplantation for Multiple Myeloma (Omar Nadeem and Jacob P. Laubach) • Introduction • ASCT in Management of Multiple Myeloma • Mobilization and Conditioning • Consolidation and Maintenance Therapy • Tandem Transplantation • Future Directions • References

Chapter 4. Allogeneic Hematopoietic Stem Cell Transplantation for Acute and Chronic Leukemias (Mahasweta Gooptu) • Introduction • Diagnosis • Special Issues • References

Chapter 5. Allogeneic Hematopoietic Stem Cell Transplantation for Myelodysplastic Syndrome (Cindy Lynn Hickey and Corey S. Cutler) • Introduction • Diagnosis • Prognosis • Treatment • References

Chapter 6. Conditioning Regimen, Graft Sources, and Alternative Donor Transplantation (Michael J. Slade and Rizwan Romee) • Introduction • Donor Classification and Selection • Graft Source • Conditioning Regimens • Future Directions • Clinical Vignette and Self-Assessment • Questions • Answers • Resources

Chapter 7. Acute Graft-Versus-Host Disease (Phuong Vo and Marco Mielcarek) • Introduction • Diagnosis • Risk Factors • Prevention • Treatment • Potential Practice Changing Clinical Trials • Clinical Vignettes and Self-Assessment • Questions • Answers • References

Chapter 8. Chronic Graft-Versus-Host Disease (Jennifer Whangbo and John Koreth) • Introduction • Diagnosis • Prognosis • Treatment • Clinical Vignettes and Self-Assessment • Questions • Answers • References

Chapter 9. Bacterial and Fungal Infections in Hematopoietic Stem Cell Transplantation Recipients (Sheila A. Bond and Lindsey R. Baden) • Introduction • Prevention • Diagnosis • Treatment • References

Chapter 10. Viral Infections After Hematopoietic Stem Cell Transplantation (Sarah P. Hammond and Francisco M. Marty) • Introduction • Diagnosis • Prognosis • Treatment and Prevention • Special Issues • Resources

Chapter 11. Pulmonary Complications After Hematopoietic Stem Cell Transplantation (Julie Ng and Raja-Elie Abdulnour) • Introduction • Infectious Pulmonary Complications • Noninfectious Pulmonary Complications • Late Noninfectious Complications • Clinical Vignettes and Self-Assessment • Questions • Answers • References

Chapter 12. Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome (Lindsey E. Roeker and Vincent T. Ho) • Introduction • Diagnosis • Treatment and Supportive Care • References

Chapter 13. Thrombotic Microangiopathy and Kidney Injury After Hematopoietic Stem Cell Transplantation (Fazilet Yilmaz, Vivek Kasinath, Merve Postalcioglu, Vincent T. Ho, and Reza Abdi) • Introduction • Diagnosis • Pathogenesis and Risk Factors • Signs and Symptoms • Incidence and Prognosis • Treatment • References

Chapter 14. Hematologic and Transfusion Issues After Hematopoietic Stem Cell Transplantation (Michael Kennah and Natasha Kekre) • Introduction • Anemia • Neutropenia • Thrombocytopenia • Thrombosis and Bleeding • Conclusion • Clinical Vignettes and Self-Assessment • Questions • Answers • Resources

Chapter 15. Posttransplant Lymphoproliferative Disorders (Jennifer L. Crombie and Ann S. LaCasce) • Introduction • Diagnosis • Presentation • Risk Factors • Prognosis • Treatment • Emerging Therapies • Conclusion • References

Chapter 16. Graft Failure (Shaikha Alotaibi, Saud Alhayli, and Mahmoud Deeb Saeed AlJurf) • Introduction • Diagnosis • Causes • Disease-Related Factors • Transplant-Related Factors • Risk Score • Treatment • References

Chapter 17. Treatment of Disease Relapse After Allogeneic Transplantation (Marlise R. Luskin and Edwin P. Alyea III) • Introduction • Predicting Risk of Relapse Using Pretransplant Data • Predicting Risk of Relapse With Posttransplant Monitoring • Treating Relapsed Disease: Timing and Approach to Chemotherapy • Treating Relapsed Disease: Enhancing Graft-Versus-Leukemia • Conclusion • References

Chapter 18. Chimeric Antigen Receptor T Therapy: Rational and Clinical Applications (Eleni Stavrou and Caron A. Jacobson) • Introduction • Current Applications and Indications • Practice Changing Trials • B-Cell Acute Lymphoblastic Leukemia • Chronic Lymphocytic Leukemia (CLL) • Special Issues: Toxicities • Resistance • Future Directions • Conclusion • References

Chapter 19. Management of Cytokine Release Syndrome (Utkarsh Acharya, Ayse Ece Cali Daylan, and Prashant Nageshwar) • Introduction • Pathogenesis • Epidemiology • Clinical Presentation • Diagnosis • Treatment • Resources

Chapter 20. Cellular Therapy Neurotoxicity: Diagnosis and Management (Daniel B. Rubin, Lauren Spendley, and Henrikas Vaitkevicius) • Introduction • Diagnosis • Prognosis • Treatment • Special Considerations • Clinical Vignettes and Self-Assessment • Questions • Answers • Resources

Chapter 21. Quality of Life and Long-Term Survivor Issues: A Review of Recommendations of Long-Term Management (Ibrahim N. Muhsen and Shahrukh K. Hashmi) • Introduction • Late Effects of HCT: Prevention and Follow-Up • The Role of LTFU Clinics • Future Research and Directions • Clinical Vignettes and Self-Assessment • Questions • Answers • References • Resources

Chapter 22. Biostatistics and Clinical Trials (Haesook T. Kim) • Introduction • Clinical Trials • References

Index


About the Editors:

Edwin P. Alyea III, MD, Chief Medical Officer, Duke Cancer Institute, Durham, North Carolina

Vincent T. Ho, MD, Clinical Director, Adult Stem Cell Transplantation, Division of Hematologic Malignancies, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts

Prashant Nageshwar, MD, Attending Physician, Department of Medical Oncology, Dana-Farber Cancer Institute; Instructor of Medicine, Harvard Medical School, Boston, Massachusetts


Target Audience:

This handbook is an essential resource for anyone managing patients being treated with stem cell transplantation or cellular therapies. This is a practical guide for clinicians and practitioners who treat cancer patients with these challenging and innovative techniques.

 
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