Title Microbiology, 5/e (International Student Edition)
Subtitle An Evolving Science
Author Joan Slonczewski, John Foster, Erik Zinser
ISBN 9780393420043
List price USD 178.50
Price outside India Available on Request
Original price
Binding Paperback
No of pages 1408
Book size 229 X 280 mm
Publishing year 2020
Original publisher W. W. Norton & Company
Published in India by .
Exclusive distributors Viva Books Private Limited
Sales territory India, Sri Lanka, Bangladesh, Pakistan, Nepal, .
Status New Arrival
About the book


A microbiology text as dynamic as the field it represents.

Striking a perfect balance, the Fifth Edition helps instructors convey exciting research in this rapidly evolving field while also motivating students to learn the fundamentals amid an overwhelming amount of information. Engaging examples, abundant eye-catching figures, updated genetics and genomics content by new coauthor Erik Zinser. An updated Smartwork5 course and new active learning resources provide flexible options for high-quality assessment in and outside of class.



Two themes run throughout the book—the gut microbiome and new marine microbiology—and connect engaging examples to important concepts in two key areas of the field (medical and ecological microbiology). Abundant eye-catching illustrations and helpful pedagogy, including Thought Questions and summary lists, help students master the core concepts in the text.



New coauthor Erik Zinser brings his experience as an active teacher and researcher to update and restructure coverage of microbial genetics and genomics. Zinser truly captures how these central topics are being studied by microbiologists today. All new chapter opening interviews and updated Special Topics put cutting-edge research and the scientists doing it front and centre, so students learn the most up-to-date science, while also engaging with the process of science.


eTopic and eAppendix Contents


About the Authors


Part 1: The Microbial Cell

Chapter 1. Microbial Life: Origin and Discovery • From Germ to Genome: What Is a Microbe? • Microbes Shape Human History • Medical Microbiology • Environment and Ecology • Special Topic 1.1: Gut Bacteria Fight Cancer • The Microbial Family Tree • Cell Biology and the DNA Revolution

Chapter 2. Observing the Microbial Cell • Observing Microbes • Optics and Properties of Light • Bright-Field Microscopy • Fluorescence Microscopy, Super-Resolution Imaging, and Chemical Imaging • Special Topic 2.1: Biogeography of a Gut Pathogen • Dark-Field and Phase-Contrast Microscopy • Electron Microscopy, Scanning Probe Microscopy, and X-Ray Crystallography

Chapter 3. Cell Structure and Function • The Bacterial Cell: An Overview • The Cell Membrane and Transport • The Envelope and Cytoskeleton • Bacterial Cell Division • Cell Polarity, Membrane Vesicles, and Nanotubes • Special Topic 3.1: Turrets and Horseshoes: What Are They For? • Specialized Structures

Chapter 4. Bacterial Culture, Growth, and Development • Microbial Nutrition • Nutrient Uptake • Culturing and Counting Bacteria • Special Topic 4.1: Antibiotic Hunters Culture the “Unculturable” • The Growth Cycle • Biofilms • Cell Differentiation

Chapter 5. Environmental Influences and Control of Microbial Growth • Environmental Limits on Growth: Temperature and Pressure • Osmolarity • Hydronium (pH) and Hydroxide Ion Concentrations • Oxygen • Nutrient Deprivation and Starvation • Physical, Chemical, and Biological Control of Microbes • Special Topic 5.1: Phage “Smart Bombs” Target Biofilms

Chapter 6. Viruses • Viruses in Ecosystems • Virus Structure • Viral Genomes and Classification • Bacteriophages: The Gut Virome • Special Topic 6.1: Phages Go Everywhere • Animal and Plant Viruses • Culturing Viruses


Part 2: Genes and Genomes

Chapter 7. Genomes and Chromosomes • DNA: The Genetic Material • Genome Organization • Special Topic 7.1: DNA as Digital Storage • DNA Replication • Plasmids and Secondary Chromosomes • Eukaryotic and Archaeal Chromosomes • Microbiomes and Metagenomes

Chapter 8. Transcription, Translation, and Protein Processing • RNA Polymerases and Sigma Factors • Transcription of DNA to RNA • Translation of RNA to Protein • Special Topic 8.1: Translocation: EF-G Gets Physical • Protein Modification, Folding, and Degradation • Secretion: Protein Traffic Control

Chapter 9. Genetic Change and Genome Evolution • Mutations • DNA Repair • Special Topic 9.1: DNA as a Live Wire: Using Electrons to Find DNA Damage • Gene Transfer: Mechanisms and Barriers • Mobile Genetic Elements • Genome Evolution

Chapter 10. Molecular Regulation • Transcription Repressors and Activators • Alternative Sigma Factors and Anti-Sigma Factors • Regulation by RNA • Second Messengers • Clocks, Thermometers, and Switches • Special Topic 10.1: Inteins, Exteins, and “Spliced-Up” Regulation • Chemotaxis: Posttranslational Regulation of Cell Behavior

Chapter 11. Viral Molecular Biology • Phage Lambda: Enteric Bacteriophage • Influenza Virus: (-) Strand RNA Virus • Special Topic 11.1: Designing a Pandemic Flu • Human Immunodeficiency Virus (HIV): Retrovirus • Endogenous Retroviruses and Gene Therapy • Herpes Simplex Virus: DNA Virus

Chapter 12. Biotechniques and Synthetic Biology • DNA Amplification and Sequence Analysis • Genetic Manipulation of Microbes • Special Topic 12.1: Constructing the Smallest Genome for Cellular Life • Gene Expression Analysis • Applied Biotechnology • Synthetic Biology: Biology by Design


Part 3: Metabolism and Biochemistry

Chapter 13. Energetics and Catabolism • Energy for Life • Energy Carriers and Electron Transfer • Catabolism: The Microbial Buffet • Glucose Fermentation and Respiration • The Gut Microbiome: Friends with Benefits • Aromatic Catabolism and Syntrophy • Special Topic 13.1: Gut Bacteria Rule Host Behavior

Chapter 14. Electron Flow in Organotrophy, Lithotrophy, and Phototrophy • Electron Transport Systems and the Proton Motive Force • The Respiratory ETS and ATP Synthase • Anaerobic Respiration • Nanowires, Electron Shuttles, and Fuel Cells • Lithotrophy and Methanogenesis • Special Topic 14.1: The Ocean Floor Is a Battery • Phototrophy

Chapter 15. Biosynthesis • Overview of Biosynthesis • CO2 Fixation: The Calvin Cycle and Other Pathways • Fatty Acids and Antibiotics • Nitrogen Fixation and Regulation • Special Topic 15.1: Mining Bacterial Genomes for Antibiotics • Amino Acids and Nitrogenous Bases

Chapter 16. Food and Industrial Microbiology • Microbial Foods • Acid- and Alkali-Fermented Foods • Ethanolic Fermentation: Bread and Wine • Food Spoilage and Preservation • Industrial Microbiology • Special Topic 16.1: Microbial Vitamins for Sale • Microbial Gene Vectors for Plants and Human Gene Therapy


Part 4: Microbial Diversity and Ecology

Chapter 17. Origins and Evolution • Origins of Life • Forming the First Cells • Evolution: Phylogeny and Gene Transfer • Natural Selection and Adaptation • Special Topic 17.1: A Giant Petri Dish and the Race to Resistance • Microbial Species and Taxonomy • Symbiosis and the Origin of Mitochondria and Chloroplasts

Chapter 18. Bacterial Diversity • Bacterial Diversity at a Glance • Cyanobacteria: Oxygenic Phototrophs • Firmicutes, Tenericutes, and Actinobacteria (Gram-Positive) • Special Topic 18.1: Gut Bacterial Hair Balls • Proteobacteria (Gram-Negative) • Spirochetes, Acidobacteria, Bacteroidetes, and Chlorobi (Deep-Branching Gram-Negative) • Planctomycetes, Verrucomicrobia, and Chlamydiae (PVC Superphylum)

Chapter 19. Archaeal Diversity • Archaeal Diversity at a Glance • TACK Hypertherrnophiles Eat Sulfur • Thaumarchaeota: Ammonia Oxidizers and Animal Symbionts • Euryarchaeota: Methanogens from Gut to Globe • Special Topic 19.1: Methanogens for Dinner • Haloarchaea and Other Euryarchaeotes: Underground and Under Ocean • DPANN Symbionts, Altiarchaeales, and Asgard: Branch to Eukaryotes?

Chapter 20. Eukaryotic Diversity • Phylogeny of Eukaryotes • Fungi • Special Topic 20.1: Yeast: A Single-Celled Human Brain • Amebas and Slime Molds • Algae • Alveolates: Ciliates, Dinoflagellates, and Apicomplexans • Parasitic Protozoa

Chapter 21. Microbial Ecology • Microbial Communities: Metagenomes and Single-Cell Sequencing • Functional Ecology • Symbiosis • Special Topic 21.1: Antarctic Lake Mats: Have Ecosystem, Will Travel • Animal Digestive Microbiomes • Marine and Freshwater Microbes • Soil and Plant Microbial Communities

Chapter 22. Element Cycles and Environmental Microbiology • The Carbon Cycle and Climate Change • The Hydrologic Cycle and Wastewater Treatment • The Nitrogen Cycle • Sulfur, Phosphorus, and Metals • Our Built Environment • Special Topic 22.1: A Microbial Jungle: The Kitchen Sponge • Astrobiology


Part 5: Medicine and Immunology

Chapter 23. The Human Microbiome and Innate Immunity • The Human Microbiome • Benefits and Risks of Microbiota • Overview of the Immune System • Special Topic 23.1: Why Do Tattoos Last Forever? • Physical and Chemical Defenses against Infection • Innate Immunity: Surveillance, Cytokines, and Inflammation • Complement and Fever

Chapter 24. The Adaptive Immune Response • Overview of Adaptive Immunity • Antibody Structure, and Diversity, and Synthesis • T Cells Link Antibody and Cellular Immune Systems • Complement as Part of Adaptive Immunity • Gut Mucosal Immunity and the Microbiome • Immunization • Hypersensitivity and Autoimmunity • Special Topic 24.1: A Monoclonal Magic Bullet for Ebola?

Chapter 25. Pathogenesis • Host-Pathogen Interactions • Microbial Attachment: First Contact • Toxins Subvert Host Functions • Special Topic 25.1: Chronic Staph Infections Work with a NET • Deploying Toxins and Effectors • Surviving within the Host • Tools Used to Probe Pathogenesis

Chapter 26. Microbial Diseases • Skin, Soft-Tissue, and Bone Infections • Respiratory Tract Infections • Gastrointestinal Tract Infections • Genitourinary Tract Infections • Cardiovascular and Systemic Infections • Special Topic 26.1: How Neutrophils Ambush Staphylococcus aureus in a Lymph Node • Central Nervous System Infections

Chapter 27. Antimicrobial Therapy and Discovery • Fundamentals of Antimicrobial Therapy • Antibiotic Mechanisms of Action • Challenges of Drug Resistance and Discovery • Special Topic 27.1: Are Designer Antibodies the Next Antibiotics? • Antiviral Agents • Antifungal Agents

Chapter 28. Clinical Microbiology and Epidemiology • Clinical Specimen Collection and Handling • Pathogen Identification by Culture and Phenotype • Molecular and Serological Identification of Pathogens • Special Topic 28.1: Next-Generation Diagnostics: CRISPR Launches a “Flare” • Epidemiology • Detecting Emerging Microbial Diseases


Appendix: Reference and Review • A Periodic Table of the Elements • Chemical Functional Groups • Amino Acids • The Genetic Code • Calculating the Standard Free Energy Change, ?G° of Chemical Reactions • Generalized Cells • Semipermeable Membranes • The Eukaryotic Cell Cycle and Cell Division


Answers to Thought Questions





About the Authors:

Joan L. Slonczewski received her BA from Bryn Mawr College and her PhD in molecular biophysics and biochemistry from Yale University, where she studied bacterial motility with Robert M. Macnab. Since completing postdoctoral work at the University of Pennsylvania, she has taught undergraduate microbiology in the Department of Biology at Kenyon College, where she earned a Silver Medal in the National Professor of the Year program of the Council for the Advancement and Support of Education. She has published numerous research articles with undergraduate coauthors on bacterial pH regulation as well as five science fiction novels, including The Highest Frontier and A Door into Ocean, both of which earned the John W. Campbell Memorial Award. She conducted fieldwork on microbial ecosystems in Antarctica, sponsored by the National Science Foundation. She has served as At-Large Member representing Divisions on the Council Policy Committee of the American Society for Microbiology and as a member of the editorial board of the journal Applied and Environmental Microbiology.

John W. Foster received his BS from the Philadelphia College of Pharmacy and Science (now the University of the Sciences in Philadelphia) and his PhD from Hahnemann University (now Drexel University School of Medicine), also in Philadelphia, where he worked with Albert G. Moat. After postdoctoral work at Georgetown University, he joined the Marshall University School of Medicine in West Virginia. He is currently teaching in the Department of Microbiology and Immunology at the University of South Alabama College of Medicine in Mobile, Alabama. Dr. Foster has coauthored three editions of the textbook Microbial Physiology and has published more than 100 journal articles describing the physiology and genetics of microbial stress responses. He has served as Chair of the Microbial Physiology and Metabolism division of the American Society for Microbiology and as a member of the editorial advisory board of the journal Molecular Microbiology.

Eric R. Zinser received his AB from Kenyon College, where he worked in the lab of coauthor Joan Slonczewski. He received his PhD in microbiology from Harvard Medical School for his research with Roberto Kolter on the evolution in Escherrichia coli during prolonged starvation. He performed his post doctoral research at MIT with Penny Chisholm on the ecology of the marine cyanobacterium Prochlorococcus. He currently teaches in the Department of Microbiology at the University of Tennessee, Knoxville. He and his students study phytoplankton and associated bacteria from marine and freshwater environments. Laboratory and field studies by his group led to development of the Black Queen Hypothesis, an evolutionary theory that explains the adaptive nature of genome streamlining in free-living microbes. He has been a member of the American Society for Microbiology since college, and has served on the editorial boards of the journals Applied and Environmental Microbiology and Environmental Microbiology.

Target Audience:

The book is for students and academicians of microbiology.

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