Title Metastasis
Subtitle Mechanism to Therapy
Author Jeffrey W. Pollard, Yibin Kang
ISBN 9781621823247
List price USD 135.00
Price outside India Available on Request
Original price
Binding Hardbound
No of pages 326
Book size 178 x 254 mm
Publishing year 2020
Original publisher Cold Spring Harbor Laboratory Press
Published in India by .
Exclusive distributors Viva Books Private Limited
Sales territory India, Sri Lanka, Bangladesh, Pakistan, Nepal, .
Status New Arrival
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Nearly all types of cancer have the ability to metastasize, or spread from one organ or tissue in the body to another. Metastatic disease is responsible for the majority of cancer deaths and, therefore, is a critical area of research. Work to better understand the metastatic cascade—how cells detach from a primary tumor, migrate through the body, and seed secondary tumors at distant locations—will lead to improved treatment options for patients with cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding the molecular mechanisms underlying metastasis and how this knowledge is paving the way for new therapeutic targets. The contributors discuss progress in defining mutations that might be driving metastasis, the formation of a premetastatic niche and how it enhances the establishment of a secondary tumor, and how changes that occur during aging increase the metastatic capacity of tumor cells. They also consider the selection and colonization of common target organs (e.g., brain, liver, and bones) during metastasis and the roles of immune cells and extracellular vesicles at different steps of the metastatic cascade. Cellular plasticity—including evidence for metastatic stem cells and the role of tumor cell dormancy in recurrent metastasis—is also covered.

In addition, the authors describe the development of in vivo models and techniques for studying metastasis, methods for monitoring tumor progression and metastatic spread (e.g., intravital microscopy and liquid biopsy), and immunotherapies that can potentially target cancer metastasis. This volume is therefore a vital reference for all cancer biologists and clinician-scientists concerned with defeating cancer.




Cancer Cell Dormancy in Metastasis (Matthew A. Summers, Michelle M. McDonald, and Peter I. Croucher)

Premetastasis (Yoshiro Maru)

Brain Metastasis Organotropism (Arseniy E. Yuzhalin and Dihua Yu)

Bone Tropism in Cancer Metastases (Hai Wang, Weijie Zhang, Igor Bado, and Xiang H.-F. Zhang)

Liver Tropism in Cancer: The Hepatic Metastatic Niche (Ainhoa Mielgo and Michael C. Schmid)

Normal Aging and Its Role in Cancer Metastasis (Mitchell Fane and Ashani T. Weeraratna)

The Immune Microenvironment and Cancer Metastasis (Asmaa El-Kenawi, Kay Hänggi, and Brian Ruffell)

Myeloid Cells in Metastasis (Agnieszka Swierczak and Jeffrey W. Pollard)

Impact of Immunometabolism on Cancer Metastasis: A Focus on T Cells and Macrophages (Nina C. Flerin, Sotiria Pinioti, Alessio Menga, Alessandra Castegna, and Massimiliano Mazzone)

Extracellular Vesicles and Metastasis (Shizhen Emily Wang)

Cancer Stem Cells and Epithelial-to-Mesenchymal Transition in Cancer Metastasis (Toni Celià-Terrassa and Mohit Kumar Jolly)

Clinical Perspectives in Brain Metastasis (Krutika Deshpande, Ian Buchanan, Vahan Martirosian, and
Josh Neman)

New Approaches on Cancer Immunotherapy (Jong-Ho Cha, Li-Chuan Chan, Min Sup Song, and
Mien-Chie Hung)

The Etiology and Impact of Muscle Wasting in Metastatic Cancer (Anup K. Biswas and Swarnali Acharyya)

The Different Facets of Liquid Biopsy: A Kaleidoscopic View (Zahra Eslami-S, Luis Enrique Cortés-Hernández, Laure Cayrefourcq, and Catherine Alix-Panabières)

Zebrafish In Vivo Models of Cancer and Metastasis (Katy R. Astell and Dirk Sieger)

Cellular Plasticity during Metastasis: New Insights Provided by Intravital Microscopy (Andreia S. Margarido, Laura Bornes, Claire Vennin, and Jacco van Rheenen)



Target Audience:

This book is an essential reference for all cancer biologists and clinician-scientists concerned with defeating cancer.


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