Title The Gene Book
Subtitle Explorations in the Code of Life (Undergraduate Text)
Author Sarah Adelaide Crawford
ISBN 9781516521012
List price USD 112.95
Price outside India Available on Request
Original price
Binding Paperback
No of pages 136
Book size 204 X 254 mm
Publishing year 2019
Original publisher Cognella Academic Publishing (Eurospan Group)
Published in India by .
Exclusive distributors Viva Books Private Limited
Sales territory India, Sri Lanka, Bangladesh, Pakistan, Nepal, .
Status New Arrival
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Description:

The Gene Book: Explorations in the Code of Life is designed to introduce undergraduate college students to foundational concepts in genetics. The text provides in-depth coverage of the essential principles of genetics, from Mendel to molecular gene therapy, and reads like a story, guiding readers through each of these areas in an interesting, engaging, and enlightening way.

Milestone scientific discoveries introduce conceptual topics in each of the 10 chapters. The significance of each genetics paradigm is reinforced by the meaningful research context in which it is placed, whether the focus is single gene inheritance of disorders such as PKU and cystic fibrosis, or more complex genetic phenomena. Chromosomes, cell division, and cytogenetic disorders, including Down Syndrome and leukemia, are presented in a riveting historical context. In addition, the principles of molecular genetics are a major focus of this book. Students learn about the double helix, DNA replication, gene expression, mutation, natural selection, genomics, and the tools of molecular DNA analysis.

Approachable and effective, The Gene Book is a highly readable comprehensive text on genetics principles designed to highlight essential concepts that make up their very core. The text is well suited to undergraduate genetics courses and can also be used as a primer for more advanced undergraduate and graduate courses in medical or molecular genetics.


Contents:

Chapter 1. Genetics Discoveries: Meeting Mendel: What Mendel’s Discoveries Taught Us About Inheritance • The Discovery of Phenylketonuria (1934) • A Visit to Mendel’s Garden So Let’s Summarize What Mendel Has Told Us So Far More than Mendel • References

Chapter 2. Pedigrees and Probability: Applications to Human Genetics • Can We Predict Human Inheritance? • What Is Cystic Fibrosis? The Discovery of Cystic Fibrosis • Pedigree Analysis • Rolling the Genetic Dice: Probability • The Genetics of Achondroplasia • How Does Genotype Determine Phenotype? • X-Linked Inheritance: Hemophilia • Summary • References

Chapter 3. Chromosomes and Inheritance • Down Syndrome • The Discovery of Chromosomes • Cells Divide to Form New Cells by Mitosis • How Are Chromosomes Inherited? • Meiosis and the Production of Reproductive Cells • Genetic Recombination • Nondisjunction: An Error in Meiosis • References

Chapter 4. Cytogenetics • Leukemia: What Do Chromosomes Have to Do with It? • Karyotype Analysis • Aneuploidies • X Chromosome Inactivation • Chromosome Structure Abnormalities • Fluorescent in Situ Hybridization (FISH) • References

Chapter 5. DNA: The Genetic Material • Important Discoveries • The Double Helix • DNA Structure • DNA Replication • Reference

Chapter 6. Unraveling the Code of Life • What Causes Cystic Fibrosis? • Cracking the Code of Life • RNA Transcription • Processing the Message: Capping and Polyadenylation • The Genetic Code • Translating the Code • References

Chapter 7. Genes and Mutations: Changing the Genetic Code • The Causes of Mutations • Types of Mutations • How Mutations Cause Disease: Sickle Cell Anemia • DNA Repair Defects • The Spectrum of Mutations: Hemoglobin

Chapter 8. Regulation of Gene Expression • The Bacterial Operon • Inducible Gene Regulation: The lac Operon Repressible Gene Regulation: The trp Operon • Gene Regulation in Eukaryotic Cells • Chromatin Remodeling Regulation of Transcription Split Genes microRNA

Chapter 9. The Gene Pool • Natural Selection • The Hardy Weinberg Equilibrium • Factors Affecting Allelic Stability • References

Chapter 10. Who am I? … The Human Genome • DNA Sequence Analysis • Structural Organization of the Human Genome • Transposons Studying the Human Genome • Functional Analysis of the Human Genome • Looking Toward the Future


About the Author:

Sarah Adelaide Crawford is professor of genetics at Southern Connecticut State University. Dr. Crawford received a Ph.D. from Columbia University College of Physicians and Surgeons, an M.S. degree in biochemistry from Princeton University, and a B.S. degree from Marymount Manhattan College. She is director of the Cancer Biology Research Laboratory and the recently opened the Autism Research Laboratory at the Southern Connecticut State University.


Target Audience:

This book is a highly readable comprehensive text on genetics principles designed to highlight essential concepts that make up their very core. The text is well suited to undergraduate genetics courses and can also be used as a primer for more advanced undergraduate and graduate courses in medical or molecular genetics.

 

 
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