Title Calcium Signaling, 2/e
Subtitle Cold Spring Harbor Perspectives in Biology
Author Geert Bultynck, Martin D. Bootman, Michael J. Berridge, Grace E. Stutzmann
ISBN 9781621822929
List price USD 135.00
Price outside India Available on Request
Original price
Binding Hardbound
No of pages 568
Book size 185 x 254 mm
Publishing year 2019
Original publisher Cold Spring Harbor Laboratory Press
Published in India by .
Exclusive distributors Viva Books Private Limited
Sales territory India, Sri Lanka, Bangladesh, Pakistan, Nepal, .
Status New Arrival
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Calcium signals—rapid changes in calcium ion concentration—are carefully orchestrated by a suite of proteins that transport and bind to calcium ions inside cells. These signals influence virtually all aspects of animal development and physiology, from fertilization and cell differentiation to muscle contraction and nerve impulses. Aberrant calcium signaling is associated with various pathologies (e.g., cancer and neurodegeneration) as well as aging.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on all facets of calcium signaling. The contributors discuss the components and activities of the various calcium-sequestering organelles inside cells, the dynamic interactions that lead to spatiotemporally distinct signals in different circumstances, and the downstream effector mechanisms that translate the signals into biological outcomes. Recent advances in the field (e.g., structural insights into the functions of certain calcium channels) are emphasized throughout.

The authors also discuss normal and perturbed calcium signaling during fertilization, development, physiology, regeneration, aging, and disease. This volume is therefore an indispensable reference for biochemists, cell and developmental biologists, and physiologists seeking a comprehensive treatment of calcium signaling.





Fundamentals of Cellular Calcium Signaling: A Primer (Martin D. Bootman and Geert Bultynck)


Calcuim Entry

Transient Receptor Potential Channels and Calcium Signaling (Laura Vangeel and Thomas Voets)

Store-Operated Calcium Channels: From Function to Structure and Back Again (Richard S. Lewis)

The Endoplasmic Reticulum–Plasma Membrane Junction: A Hub for Agonist Regulation of Ca2+ Entry (Hwei Ling Ong and Indu Suresh Ambudkar)

Signaling through Ca2+ Microdomains from Store-Operated CRAC Channels (Pradeep Barak and Anant B. Parekh)


Calcuim Release

Structure and Function of IP3 Receptors (David L. Prole and Colin W. Taylor)

NAADP Receptors (Antony Galione)

Bcl-2-Protein Family as Modulators of IP3 Receptors and Other Organellar Ca2+ Channels (Hristina Ivanova, Tim Vervliet, Giovanni Monaco, Lara E. Terry, Nicolas Rosa, Mariah R. Baker, Jan B. Parys, Irina I. Serysheva, David I. Yule, and Geert Bultynck)


Calcuim Stores and Calcuim Transport

Primary Active Ca2+ Transport Systems in Health and Disease (Jialin Chen, Aljona Sitsel, Veronick Benoy, M. Rosario Sepúlveda, and Peter Vangheluwe)

Cytoplasmic and Mitochondrial Calcium Signaling: A Two-Way Relationship (Benjamin Wacquier, Laurent Combettes, and Geneviève Dupont)

Lysosomal Ca2+ Homeostasis and Signaling in Health and Disease (Emyr Lloyd-Evans and Helen Waller-Evans)

Cytosolic Ca2+ Buffers Are Inherently Ca2+ Signal Modulators (Beat Schwaller)

Organellar Calcium Handling in the Cellular Reticular Network (Wen-An Wang, Luis B. Agellon, and Marek Michalak)


Downstream Effectors of Calcuim

Structural Insights into the Regulation of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) (Moitrayee Bhattacharyya, Deepti Karandur, and John Kuriyan)

Calcium Sensors in Neuronal Function and Dysfunction (Robert D. Burgoyne, Nordine Helassa, Hannah V. McCue, and Lee P. Haynes)

Identifying New Substrates and Functions for an Old Enzyme: Calcineurin (Jagoree Roy and Martha S. Cyert)


Physiological Processes Regulated by Calcuim

Ca2+ Signaling and Homeostasis in Mammalian Oocytes and Eggs (Takuya Wakai, Aujan Mehregan, and Rafael A. Fissore)

Role of Two-Pore Channels in Embryonic Development and Cellular Differentiation (Sarah E. Webb, Jeffrey J. Kelu, and Andrew L. Miller)

Functional Consequences of Calcium-Dependent Synapse-to-Nucleus Communication: Focus on Transcription-Dependent Metabolic Plasticity (Anna M. Hagenston, Hilmar Bading, and Carlos Bas-Orth)

Calcium Signaling in Cardiomyocyte Function (Guillaume Gilbert, Kateryna Demydenko, Eef Dries, Rosa Doñate Puertas, Xin Jin, Karin Sipido, and H. Llewelyn Roderick)

Ca2+ Signaling in Exocrine Cells (Malini Ahuja, Woo Young Chung, Wei-Yin Lin, Beth A. McNally, and Shmuel Muallem)

Ca2+ Signaling and Regeneration (Jonathan S. Marchant)


Calcuim and Disease

Creating a New Cancer Therapeutic Agent by Targeting the Interaction between Bcl-2 and IP3 Receptors (Clark W. Distelhorst and Martin D. Bootman)

The Calcium-Signaling Toolkit in Cancer: Remodeling and Targeting (Sarah J. Roberts-Thomson, Silke B. Chalmers, and Gregory R. Monteith)

Calcium-Handling Defects and Neurodegenerative Disease (Sean Schrank, Nikki Barrington, and Grace E. Stutzmann)

Calcium Signaling and Tissue Calcification (Diane Proudfoot)

Astroglial Calcium Signaling in Aging and Alzheimer’s Disease (Alexei Verkhratsky)


Target Audience:

This book is an indispensable reference for a biochemists, cell and developmental biologists, pathologists and physiologists seeking a comprehensive treatment of calcium signaling and also useful for people interested in cell & molecular biology and biochemistry.


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