Title Multiple Sclerosis and Related Disorders, 2/e
Subtitle Clinical Guide to Diagnosis, Medical Management, and Rehabilitation
Author Robert J. Fox, Alexander D. Rae-Grant, Francois Bethoux
ISBN 9780826125934
List price USD 99.00
Price outside India Available on Request
Original price USD 99.00
Binding Paperback
No of pages 424
Book size 204 X 254 mm
Publishing year 2019
Original publisher Demos Medical Publishing
Published in India by .
Exclusive distributors .
Sales territory Bangladesh, India, Pakistan, Sri Lanka
Status New Arrival
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Revised and updated second edition of Multiple Sclerosis and Related Disorders: Clinical Guide to Diagnosis, Medical Management, and Rehabilitation, the only comprehensive but practical source of core information on multiple sclerosis and other demyelinating disorders. Intended as a ready reference for clinicians who provide ongoing care to MS patients, this book combines evidence-based science with experience-based guidance to present current standards and management protocols from leading MS centers.

Beginning with the scientific underpinnings of MS for clinicians, the book proceeds through diagnosis, including initial symptoms, criteria and classification, imaging, and differential diagnosis, and onto approved treatments for the various MS types and emerging therapies. Later parts of the book discuss symptom management and rehabilitation with chapters focusing on specific side effects, along with considerations for special populations, comorbidities, societal and family issues, and related autoimmune disorders that are often mistaken for MS.

Throughout, chapters include lists of Key Points both for clinicians and for patients and families, and management pearls are boxed for quick reference and clinical utility. Illustrations, tables, algorithms, assessment scales, and up-to-date MRI imaging enrich the text, making this a wide-ranging clinical reference for all members of the MS care team.

New to the Second Edition:

  • Includes summary recommendations from new AAN practice guidelines for use of DMTs
  • All chapters updated to reflect the latest literature and diagnostic criteria
  • Five entirely new chapters added to expand coverage of treatment, rehabilitation and symptom management, and special issues related to MS
  • Treatment section has been completely revised to better capture current approaches to disease modifying therapies, with separate chapters devoted to injection and oral therapies, infusion therapies, and treatments for progressive forms of MS
  • Related diseases section significantly expanded to include transverse myelitis, autoimmune encephalitis, and neurosarcoidosis




Foreword J. Theodore Phillps, MD, PhD, FAAN


Share Multiple Sclerosis and Related Disorders: Clinical Guide to Diagnosis, Medical Management, and Rehabilitation, Second Edition

PART I. Basics for Clinicians

Chapter 1. History of Multiple Sclerosis (T. Jock Murray)

Chapter 2. Overview of Multiple Sclerosis (Alexander D. Rae-Grant and Robert J. Fox)

Chapter 3. Pathology and Pathophysiology of Multiple Sclerosis (Kedar R. Mahajan and Don J. Mahad)

Chapter 4. Epidemiology and Natural History of Multiple Sclerosis (Marcus W. Koch)

Chapter 5. Multiple Sclerosis Genetics (Bruce A. C. Cree)


PART II. Diagnosis

Chapter 6. Symptoms and Signs of Multiple Sclerosis (Marisa P. McGinley and Lael A. Stone)

Chapter 7. Diagnosis of Multiple Sclerosis (Thomas Shoemaker and Scott D. Newsome)

Chapter 8. Magnetic Resonance Imaging in Multiple Sclerosis (Christopher J. Karakasis, Aliye O. Bricker, and Stephen E. Jones)

Chapter 9. Tools and Tests for Multiple Sclerosis (Robert A. Bermel) Chapter 10. Differential Diagnosis of Multiple Sclerosis (Megan H. Hyland and Jeffrey A. Cohen)

PART III. Treatment

2018 American Academy of Neurology Guidelines for Multiple Sclerosis Disease-Modifying Therapy (Alexander D. Rae-Grant)


Chapter 11. Approach to Disease-Modifying Therapy (Laura E. Baldassari and Jeffrey A. Cohen)

Chapter 12. Relapse Management in Multiple Sclerosis (Andrew L. Smith and Robert J. Fox)

Chapter 13. Treating Relapsing Forms of Multiple Sclerosis: Injection and Oral Therapies (Le H. Hua)

Chapter 14. Treating Relapsing Forms of Multiple Sclerosis: Infusion Therapies (Jenny J. Feng and Daniel Ontaneda)

Chapter 15. Treating Progressive Multiple Sclerosis (Carrie M. Hersh)

Chapter 16. Emerging Therapies (Michael D. Kornberg and Peter A. Calabresi)


PART IV. Rehabilitation and Symptom Management

Chapter 17. Overview of Rehabilitation in Multiple Sclerosis (Francois Bethoux)

Chapter 18. Relationship-Centered Care in a Multiple Sclerosis Comprehensive Care Center (Adrienne Boissy and Claire Hara-Cleaver)

Chapter 19. Fatigue in Multiple Sclerosis (Matthew Plow and Aaron Nicka)

Chapter 20. Emotional Disorders in Multiple Sclerosis (Elias A. Khawam and Matthew Sacco)

Chapter 21. Cognitive Dysfunction in Multiple Sclerosis (Stephen M. Rao)

Chapter 22. Epilepsy, Sleep Disorders, and Transient Neurological Events in Multiple Sclerosis (Burhan Z. Chaudhry and Alexander D. Rae-Grant)

Chapter 23. Eye Symptoms, Signs, and Therapy in Multiple Sclerosis (Collin M. McClelland and Steven L. Galetta)

Chapter 24. Bulbar and Pseudobulbar Dysfunction in Multiple Sclerosis (Devon S. Conway)

Chapter 25. Pain Management in Multiple Sclerosis (John F. Foley, Ryan R. Metzger, Kara Menning, Cortnee Roman, and Emily N. Stuart)

Chapter 26. Upper Extremity Function in Multiple Sclerosis (Christine Smith and Kathleen M. Zackowski)

Chapter 27. Bladder and Bowel Dysfunction in Multiple Sclerosis (Courtenay K. Moore)

Chapter 28. Sexual Dysfunction and Other Autonomic Disorders in Multiple Sclerosis (Samantha Domingo and Carolyn Fisher)

Chapter 29. Spasticity Management in Multiple Sclerosis (Francois Bethoux and Mary Alissa Willis)

Chapter 30. Multiple Sclerosis and Mobility (Francois Bethoux, Jacob J. Sosnoff, and Keith McKee)

Chapter 31. General Health and Wellness in Multiple Sclerosis (Mary R. Rensel, Brandon P. Moss, and Carrie M. Hersh)

Chapter 32. Complementary and Alternative Medicine: Practical Considerations (Allen C. Bowling)

PART V. Special Issues Chapter 33. Pediatric Multiple Sclerosis (Amy T. Waldman) Chapter 34. Women’s Issues (Megan E. Esch, Bridgette Jeanne Billioux, and Ellen M Mowry) Chapter 35. Multiple Sclerosis and Associated Comorbidities (Yuval Karmon, Caila B. Vaughn, Shumita Roy, Svetlana Primma Eckert, and Bianca Weinstock-Guttman) Chapter 36. Work, Insurance, and Disability Issues in Multiple Sclerosis (Matthew H. Sutliff and Deborah M. Miller) Chapter 37. Caregiving in Multiple Sclerosis (Amy Burleson Sullivan)

Part VI. Related Diseases

Chapter 38. Neuromyelitis Optica (Amanda L. Piquet and John R. Corboy)

Chapter 39. Acute Disseminated Encephalomyelitis (Eliza Gordon-Lipkin and Brenda Banweh)

Chapter 40. Transverse Myelitis (Isabella Strozzi and Michael Levy)

Chapter 41. Autoimmune Encephalitis (Michel Toledano)

Chapter 42. Neurosarcoidosis (Brandon P. Moss and Jinny Tavee)




About the Editors:

Robert J. Fox, MD, MSc is Staff Neurologist, Mellen Center for MS Treatment and Research, Vice-Chair for Research, Neurological Institute, Cleveland Clinic Foundation, Cleveland, Ohio.


Francois Bethoux, MD is Professor, Cleveland Clinic Lerner College of Medicine, Director of Rehabilitation Services, Mellen Center for MS Treatment and Research, Cleveland Clinic Foundation, Cleveland, Ohio.


Alexander D. Rae-Grant, MD, FRCP(C) is Staff Neurologist, Director of MS Education, Mellen Center for MS Treatment and Research, Cleveland Clinic Foundation, Cleveland, Ohio.

Target Audience:

It is intended as a ready reference for clinicians who provide ongoing care to Multiple Sclerosis patients. It is useful for neurologists and physical medicine & rehabilitation professionals.

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