Title Case Studies in Cancer
Subtitle
Author Richard J. Lee, Jeremy S. Abramson, Richard A. Goldsby
ISBN 9780393679519
List price USD 72.50
Price outside India Available on Request
Original price
Binding Paperback
No of pages 368
Book size 216 x 279 mm
Publishing year 2019
Original publisher W. W. Norton & Company
Published in India by .
Exclusive distributors Viva Books Private Limited
Sales territory India, Sri Lanka, Bangladesh, Pakistan, Nepal, .
Status New Arrival
About the book
  
 

Description:

The modern diagnosis and treatment of cancer is intricately tied to the molecular underpinnings of disease. Case Studies in Cancer highlights the broad range of malignancies in which known molecular pathways contribute to tumorigenesis as well as susceptibility or resistance to therapy.

  • Every case highlights the relationship between the underlying molecular biology and the disease diagnosis and treatment.
  • A logical, consistent organization of the cases ensures the translation from “bench to bedside.”
  • The authors’ combined experience in clinical practice , cancer research, and in teaching makes them uniquely qualified to write this important new book.


Contents:

Preface

About the Authors

Chapter 1. Overview of Cancer and Clinical Oncology • Introduction • Cancer facts and figures • Clinical oncology • The hallmarks of cancer • The tumor microenvironment • Diagnosis, workup, and staging • Role of cancer screening • Biomarkers • Development of cancer therapies • The future of clinical oncology • Chapter discussion questions • Selected references

Chapter 2. Introduction to Cancer Therapy • Introduction • Surgery • Radiation therapy • Medical cancer therapies • Genomics and oncology • Cytogenic approaches • Microarrays • Sequencing • NGS technologies • Genomics • Genomic assays of circulating tumor cells and tumor DNA • Pharrnacogenomics and cancer therapy • Summary and future prospects • Chapter discussion questions • Selected references

Chapter 3. Cytotoxic Chemotherapy • Introduction • CASE 3-1 Testicular Cancer • Introduction • Epidemiology and etiology • Diagnosis, workup, and staging • Management of stage I and II testicular cancer • Management of stage III testicular cancer • The case of Michael LaPorta, a healthy young man with a painless scrotal mass • Targeted therapy and testicular cancer • Future prospects and challenges in metastatic testicular cancer • Discussion questions • CASE 3-2 Pancreatic Cancer • Introduction • Epidemiology and etiology • Diagnosis, workup, and staging • Management of localized pancreatic cancer • Management of metastatic pancreatic cancer • The case of Jeanne Brantley, a real estate broker with painless jaundice • Targeted therapy and pancreatic cancer • Future prospects and challenges in metastatic pancreatic adenocarcinoma • Discussion questions • Chapter summary • Chapter discussion questions • Selected references

Chapter 4. Protein Kinase Inhibition • Introduction • CASE 4-1 Chronic Myelogenous Leukemia • Introduction • Epidemiology • Diagnosis, workup, and staging • Management of CML in chronic phase • The case of Jeffrey Paul, a man with a twisted ankle and an elevated white blood cell count • Management of accelerated- and blast-phase CML • Management of CML when initial TKI therapy fails • Future prospects and challenges in CML • Discussion questions • CASE 4-2 Chronic Lymphocytic Leukemia • Introduction • Epidemiology • Diagnosis, workup, and staging • Principles of CLL management • The case of Patricia O’Halloran, a 68-year-old professor of German history with an elevated WBC count • Treatment of relapsed CLL • Future prospects and challenges in CLL • Discussion questions • CASE 4-3 Lung Cancer • Introduction and epidemiology • Diagnosis, workup, and staging • Management of localized lung cancer • Management of metastatic lung cancer • Genetic alterations and NSCLC • The case of Alex Washington, a nonsmoker with a lingering cough • EML4-ALK translocation-positive NSCLC • Future prospects and challenges in lung cancer • Discussion questions • CASE 4-4 Metastatic Melanoma • Introduction and epidemiology • Diagnosis, workup, and staging • Management of localized melanoma • Management of metastatic melanoma • Genetic alterations and melanoma • The case of Tom Schaeffer, a retired machinist with an irregular brown skin lesion • Kinase inhibition and melanoma • Future prospects and challenges in metastatic melanoma • Discussion questions • Chapter summary • Chapter discussion questions • Selected references

Chapter 5. Inhibition of the PI3-Kinase/Akt/mTOR Pathway • Introduction • CASE 5-1 Renal Cell Carcinoma • Introduction • Diagnosis: workup, and staging • Management of localized RCC • Management of metastatic RCC • Molecular alterations and RCC • The case of Mary Carlton, a woman with an incidental kidney mass found during evaluation of abdominal pain • Targeted therapies and metastatic RCC • Future prospects and challenges in metastatic RCC • Discussion questions • CASE 5-2 Follicular Lymphoma Introduction • Epidemiology • Diagnosis, workup, and staging • Principles of FL management • The case of Stephen Kim, a community organizer with kidney stones PI3-kinase inhibition in follicular lymphoma • Future prospects and challenges in follicular lymphoma • Discussion questions • Chapter summary • Chapter discussion questions • Selected references

Chapter 6. Hormone Therapy • Introduction • Inhibition of gonadotropin release • Steroidogenesis inhibition • Inhibition of conversion of steroids in peripheral tissues • Steroid hormone receptor antagonists • CASE 6-1 Breast Cancer • Introduction • Etiology • Diagnosis, workup, and staging • Breast cancer subtypes • Management of localized breast cancer • Management of metastatic breast cancer • The case of Brenda Nathan, a paramedic with a breast mass • Hormone therapy and metastatic breast cancer • Future prospects and challenges in metastatic breast cancer • Discussion questions • CASE 6-2 Prostate Cancer • Introduction • Diagnosis, workup, and staging • Management of localized prostate cancer • Management of metastatic prostate cancer • The case of Adam Presley, a retired high school principal with hip pain • AR targeting and prostate cancer: beyond ADT • Future prospects and challenges in metastatic prostate cancer • Discussion questions • Chapter summary • Chapter discussion questions • Selected references

Chapter 7. Differentiation Therapy • Introduction • CASE 7-1 Acute Promyelocytic Leukemia • Introduction • Epidemiology and etiology • Diagnosis, workup, and staging • Initial treatment of APL • The case of Mark Gable, a young man with bleeding gums following dental cleaning • Management of relapsed APL • Discussion questions • Chapter summary • Chapter discussion questions • Selected references

Chapter 8. Epigenetic Therapy • Introduction • Histone modification • DNA methylation • MicroRNA (miRNA) targeting • Long noncoding RNAs (IncRNAs) • CASE 8-1 Myelodysplastic Syndromes • Introduction and epidemiology • Diagnosis and workup • Prognosis • The case of Hank Johnson, an older male with dyspnea on exertion and progressive cytopenias • Treatment • Future prospects and challenges in MDS • Discussion questions •
CASE 8-2 Cutaneous T-cell Lymphoma • Introduction • Epidemiology • Diagnosis, workup, and staging • Principles of MF and SS management • The case of Jon Carter, a 62-year-old man with skin lesions • HDAC inhibition in cutaneous MF and SS • Future prospects and challenges in cutaneous T-cell lymphomas • Discussion questions • Chapter summary • Chapter discussion questions • Selected references

Chapter 9. Targeting Protein Degradation and DNA Repair • Introduction • CASE 9-1 Hereditary Breast Cancer • Introduction • Epidemiology of BRCA-associated cancers • Recommendations for BRCA1/2 asymptomatic carriers • The Case of Yvonne Charles, a young mother with a breast lump • Neoadjuvant therapy for breast cancer • Management of localized BRCA1/2-related breast cancer • Management of metastatic BRCA1/2-related breast cancer • Future prospects and challenges in BRCA-mutant cancers • Discussion questions • CASE 9-2 Multiple Myeloma • Introduction • Epidemiology and etiology • Diagnosis, workup, and staging • Initial management of multiple myeloma • The Case of Malik Jackson, a 39-year-old man who presented with anemia and multiple lytic bone lesions • Proteasome inhibition and multiple myeloma • Future prospects and challenges in multiple myeloma • Discussion questions • Chapter summary • Chapter discussion questions • Selected references

Chapter 10. Interference with the Tumor Microenvironment • Introduction • The immunosuppressive TME • Angiogenesis in the TME • Targeting and disturbing the TME • CASE 10-1 Colorectal Cancer • Introduction • Molecular alterations and CRC • Epidemiology and etiology • Diagnosis, workup, and staging • Management of Localized CRC • Management of metastatic CRC • The case of Mary Maspin, a woman with blood in her stool and an unintentional 20-pound weight loss • Targeted therapies and metastatics CRC • Future prospects and challenges in metastatic CRC treatment • Discussion questions • CASE 10-2 Multiple Myeloma • Introduction • Principles of management for transplant-ineligible patients with newly diagnosed MM • The role of IMiDs in multiple myeloma therapy • The case of Tom Brown, a 70-year-old male with a history of monoclonal gammopathy and severe low back pain • The bone marrow microenvironment in multiple myeloma • Bone metabolism • Immunomodulatory drugs and the bone marrow microenvironment • Future prospects and challenges in treating multiple myeloma • Discussion Questions • Chapter summary • Chapter discussion questions • Selected references

Chapter 11. Immunological Strategies: Monoclonal Antibodies • Introduction • CASE 11-1 Non-Hodgkin Lymphoma • Introduction • Epidemiology • Diagnosis, workup, and Staging • Priciples of DLBCL management • The case of Linda White, a 61-year-old school teacher with pain in her shoulder • Management of relapsed DLBCL • Future prospects and challenges in DLBCL • Discusion questions • CASE 11-2 Hodgkin Lymphoma • Introduction • Epidemiology • Diagnosis, workup, and staging • Principles of CHL management • The case of Jessica Romero, a 22-year-old graduate student with shortness of breath • Treatment of relapsed Hodgkin lymphoma • Future prospects and challenges in CHL • Discussion questions • CASE 11-3 Breast Cancer • The case of Julie Rosen, a 53-year-old woman with a growing breast mass and a family history of breast cancer • Future prospects and challenges in breast cancer • Discussion questions • Chapter summary • Chapter discussion questions • Selected references

Chapter 12. Immunological Strategies: Vaccination and Adoptive T-Cell Transfer • Introduction • Cancer vaccines • Adoptive T-cell therapies • Blockade of immune checkpoints • Other immunotherapies • CASE 12-1 Cervical Cancer • Introduction • Epidemiology and etiology • Diagnosis, workup, and staging • Cell biology of HPV • Management of localized cervical cancer • Management of advanced cervical cancer • The case of Pamela Johnson, a 38-year-old woman with abnormal Pap smear findings • HPV vaccination and prevention of cervical cancer • Future prospects and challenges in HPV vaccines • Discussion questions • CASE 12-2 Acute Lymphoblastic Leukemia • Introduction and epidemiology • Diagnosis, workup, and staging • Management of ALL • The case of Roger Gonzales, a 5-year-old boy with fatigue, pallor, and bruising • Treatment with CAR T cells • Discussion questions • CASE 12-3 Metastatic Melanoma • Introduction • The case of Adam Stephenson, a 66-year-old man with a growing lesion on his left shoulder • Immunotherapy and melanoma • Future prospects and challenges in metastatic melanoma • Discussion questions • Chapter summary • Chapter discussion questions • Selected references

Glossary

Index


About the Authors:

Richard J. Lee After completing a bachelor’s and a master’s degree at Harvard, Dr. Lee then completed his medical school (M.D.) and graduate school (Ph.D.) training at the Albert Einstein College of Medicine, Bronx, New York. He came to Massachusetts General Hospital for internal medicine residency training and then completed medical oncology fellowship training through the Dana-Farber/Harvard Cancer Center joint program. After a postdoc with Dr. Robert A. Weinberg at the Whitehead Institute, he joined the medical oncology faculty at the Massachusetts General Hospital Cancer Center. Dr. Lee is currently Assistant Professor of Medicine at Harvard Medical School.

Jeremy S. Abramson is Director of the Lymphoma Program and holds the Jon and Jo Ann Hagler Chair in Lymphoma at the Massachusetts General Hospital Cancer Center. He is also Assistant Professor of Medicine at Harvard Medical School. Dr. Abramson earned his medical degree from the Mount Sinai School of Medicine in New York and a Master of Medical Science degree from Harvard Medical School. His research focuses on the development of novel targeted therapies and cellular immunotherapy for lymphoid malignancies.

Richard A. Goldsby received a Ph.D. in chemistry at the University of California-Berkeley. He is the Thomas B. Walton Jr. Memorial Professor of Biology Emeritus at Amherst College, coauthored three editions of a leading immunology textbook, and was a cofounder of Hematech. He is also Adjunct Professor of Veterinary and Animal Sciences at the University of Massachusetts-Amherst and Visiting Scientist at the Whitehead Institute, Cambridge, Massachusetts.


Target Audience:

Students and academicians of oncology.

 

 
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