Title Bioelectronic Medicine
Author Valentin A. Pavlov, Kevin J. Tracey
ISBN 9781621823025
List price USD 135.00
Price outside India Available on Request
Original price
Binding Hardbound
No of pages 348
Book size 178 x 254 mm
Publishing year 2019
Original publisher Cold Spring Harbor Laboratory Press
Published in India by .
Exclusive distributors Viva Books Private Limited
Sales territory India, Sri Lanka, Bangladesh, Pakistan, Nepal, .
Status New Arrival
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Every organ in the human body is innervated by the nervous system and communicates with the brain via electrical signals. Various devices can be used to modulate these electrical signals and elicit changes in organ function with the aim of treating injury or disease. This approach is the basis of the rapidly emerging field of bioelectronic medicine, which has the potential to diagnose and treat medical conditions more precisely and effectively than ever before.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers many aspects of bioelectronic medicine, examining the neuronal pathways that are being targeted for manipulation, the electronic neuromodulation devices that are under development, and how all of this work is leading to new diagnostics and treatment options for patients. The contributors discuss how the stimulation of specific nerves (e.g., the vagus nerve) has been successfully used to treat certain conditions (e.g., rheumatoid arthritis and Crohn’s disease) and how similar strategies are being investigated as therapeutics for a multitude of gastrointestinal, cardiovascular, respiratory, and renal disorders. They consider implantable devices, magnetoelectric nanoparticles, ultrasound, optogenetic-based approaches, and electrophotonic devices as tools for acquiring, decoding, and modulating electrical signals from nerves and how they might be used to monitor and treat patients in the clinic.

The authors also discuss the ethical concerns related to the use of technologies such as these that can alter the brain. The volume is therefore an indispensable reference for neuroscientists, biomedical engineers, and physicians interested in the benefits and challenges of recording, stimulating, and blocking electrical activity in the human body.



Chapter 1: Bioelectronic Medicine: From Preclinical Studies on the Inflammatory Reflex to New Approaches in Disease Diagnosis and Treatment (Valentin A. Pavlov, Sangeeta S. Chavan, and Kevin J. Tracey)

Chapter 2: Optogenetic Control of the Peripheral Nervous System (Rui B. Chang)

Chapter 3: Optogenetic Medicine: Synthetic Therapeutic Solutions Precision-Guided by Light (Haifeng Ye and Martin Fussenegger)

Chapter 4: Electromagnetic Regulation of Cell Activity (Sarah A. Stanley and Jeffrey M. Friedman)

Chapter 5: Recording and Decoding of Vagal Neural Signals Related to Changes in Physiological Parameters and Biomarkers of Disease (Theodoros P. Zanos)

Chapter 6: Closed-Loop Neuromodulation in Physiological and Translational Research (Stavros Zanos)

Chapter 7: Bioelectronic Approaches to Control Neuroimmune Interactions in Acute Kidney Injury
(Tsuyoshi Inoue, Shinji Tanaka, Diane L. Rosin, and Mark D. Okusa)

Chapter 8: Small Heat Shock Proteins, Amyloid Fibrils, and Nicotine Stimulate a Common Immune Suppressive Pathway with Implications for Future Therapies (Jonathan B. Rothbard, Michael P. Kurnellas, Shalina S. Ousman, Sara Brownell, Jesse J. Rothbard, and Lawrence Steinman)

Chapter 9: Noninvasive Neuromodulation of Peripheral Nerve Pathways Using Ultrasound and Its Current Therapeutic Implications (Christopher Puleo and Victoria Cotero)

Chapter 10: Vagus Nerve Stimulation and the Cardiovascular System (Michael J. Capilupi,
Samantha M. Kerath, and Lance B. Becker)

Chapter 11: Empirically Based Guidelines for Selecting Vagus Nerve Stimulation Parameters in Epilepsy and Heart Failure (Eric D. Musselman, Nicole A. Pelot, and Warren M. Grill)

Chapter 12: Neural Control of Inflammation: Bioelectronic Medicine in Treatment of Chronic Inflammatory Disease (Michael Eberhardson, Laura Tarnawski, Monica Centa, and Peder S. Olofsson)

Chapter 13: Harnessing the Inflammatory Reflex for the Treatment of Inflammation-Mediated Diseases (Yaakov A. Levine, Michael Faltys, and David Chernoff)

Chapter 14: Vagus Nerve Stimulation at the Interface of Brain–Gut Interactions (Bruno Bonaz, Valérie Sinniger, and Sonia Pellissier)

Chapter 15: Enteric Neuromodulation for the Gut and Beyond (Yogi A. Patel and Pankaj J. Pasricha)

Chapter 16: Use of Bioelectronics in the Gastrointestinal Tract (Larry Miller, Aydin Farajidavar, and Anil Vegesna)

Chapter 17: Microscale and Nanoscale Electrophotonic Diagnostic Devices (Kaiyu Fu, Wei Xu, Jiayun Hu, Arielle Lopez, and Paul W. Bohn)

Chapter 18: Electrical Impedance Methods in Neuromuscular Assessment: An Overview (Seward B. Rutkove and Benjamin Sanchez)

Chapter 19: Technobiology’s Enabler: The Magnetoelectric Nanoparticle (Sakhrat Khizroev)

Chapter 20: Restoring Movement in Paralysis with a Bioelectronic Neural Bypass Approach: Current State and Future Directions (Chad E. Bouton)

Chapter 21: Diabetes Technology: Monitoring, Analytics, and Optimal Control (Boris Kovatchev)

Chapter 22: Bioelectronic Medicine—Ethical Concerns (Samuel Packer, Nicholas Mercado, and Anita Haridat)


Target Audience:

This book is an indispensable reference for neuroscientists, biomedical engineers, and physicians interested in the benefits and challenges of recording, stimulating, and blocking electrical activity in the human body.

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